Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8283102 | 0.76 | SLC6A4 (0.60) | POLBTSHRCYP1A2CYP2D6CYP2C19 | |
| SCHEMBL7976221 | 0.76 | SLC6A4 (0.60) | POLBTSHRCYP1A2CYP2D6CYP2C19 | |
| SCHEMBL3314264 | 0.72 | CYP1A2 (0.47) | MAPTKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL31590889 | 0.71 | HDAC8 (0.51) | MAPTKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL18664479 | 0.71 | HDAC8 (0.51) | MAPTKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL12301203 | 0.71 | MAPT (0.58) | MAPTKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL28404311 | 0.71 | MAPT (0.52) | MAPTKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL6129140 | 0.69 | MAPT (0.44) | MAPTKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL3318333 | 0.69 | SLC6A4 (0.45) | MAPTKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL1609235 | 0.68 | ALDH1A1 (0.60) | MAPTKDM4EALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7399778-B2 | Heterocyclic sulfonamide inhibitors of beta amyloid production containing an azole | WYETH (US) | 2008-07-15 | — | — | US | disclosed |