SCHEMBL4576228

SCHEMBL4576228

NC(=O)C(=O)NCc1ccccc1OC(F)(F)F

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC3 O15379 1/20 0.50
HDAC1 Q13547 1/20 0.50
HDAC2 Q92769 1/20 0.50
HDAC6 Q9UBN7 1/20 0.50
EPHX2 P34913 10/20 0.49
PPARG P37231 2/20 0.49
CYP2C9 P11712 3/20 0.47
CYP2J2 P51589 3/20 0.47
NTRK1 P04629 2/20 0.47
ALOX5 P09917 1/20 0.47
CYP3A4 P08684 1/20 0.47
CYP2C19 P33261 1/20 0.47
HSD17B13 Q7Z5P4 1/20 0.46
ADORA2A P29274 1/20 0.45
ADORA2B P29275 1/20 0.45
ADORA1 P30542 1/20 0.45
ROCK2 O75116 1/20 0.44
ROCK1 Q13464 1/20 0.44
BRD4 O60885 1/20 0.43
CREBBP Q92793 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15716447 0.88 HDAC3 (0.52) HDAC3HDAC1HDAC2HDAC6EPHX2
SCHEMBL15682836 0.87 NTRK1 (0.49) HDAC3HDAC1HDAC2HDAC6EPHX2
SCHEMBL4659240 0.82 HDAC3 (0.46) HDAC3HDAC1HDAC2HDAC6EPHX2
SCHEMBL17468449 0.82 PPARG (0.54) HDAC3HDAC1HDAC2HDAC6EPHX2
SCHEMBL15682824 0.81 EPHX2 (0.57) HDAC3HDAC1HDAC2HDAC6EPHX2
SCHEMBL2204065 0.80 NPSR1 (0.64) HDAC1
SCHEMBL9903526 0.79 HDAC3 (0.50) HDAC3HDAC1HDAC2HDAC6EPHX2
SCHEMBL22369026 0.79 NTRK1 (0.56) HDAC3HDAC1HDAC2HDAC6EPHX2
SCHEMBL17680717 0.79 PPARG (0.55) HDAC3HDAC1HDAC2HDAC6EPHX2
SCHEMBL19531682 0.79 TSHR (0.56) HDAC3HDAC1HDAC2HDAC6EPHX2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1673085-A4 C-MET MODULATORS AND METHODS OF USE EXELIXIS INC (US) 2008-12-10 EP claimed
EP-1673085-A2 C-MET MODULATORS AND METHODS OF USE Exelixis, Inc. (US) 2006-06-28 EP claimed
WO-2005030140-A2 C-MET MODULATORS AND METHODS OF USE EXELIXIS, INC. (US) 2005-04-07 WO claimed
EP-1673085-A4 C-MET MODULATORS AND METHODS OF USE EXELIXIS INC (US) 2008-12-10 EP disclosed
EP-1673085-A2 C-MET MODULATORS AND METHODS OF USE Exelixis, Inc. (US) 2006-06-28 EP disclosed
WO-2005030140-A2 C-MET MODULATORS AND METHODS OF USE EXELIXIS, INC. (US) 2005-04-07 WO disclosed