Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.64 |
| ▸ | HPGD | P15428 | 6/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.61 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | HTT | P42858 | 2/20 | 0.60 |
| ▸ | NPC1 | O15118 | 2/20 | 0.60 |
| ▸ | RAB9A | P51151 | 2/20 | 0.60 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 2/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1520822 | 0.87 | NPSR1 (0.68) | NPSR1HPGDALDH1A1KDM4ERCE1 | |
| SCHEMBL10163441 | 0.85 | HPGD (0.65) | NPSR1HPGDALDH1A1KDM4ERCE1 | |
| SCHEMBL169897 | 0.84 | MTNR1A (0.70) | HPGDALDH1A1KMT2AMEN1HTT | |
| SCHEMBL8477018 | 0.83 | HPGD (0.61) | NPSR1HPGDALDH1A1KDM4ERCE1 | |
| SCHEMBL885000 | 0.81 | MTNR1A (0.71) | NPSR1HPGDALDH1A1KDM4ERCE1 | |
| SCHEMBL13434069 | 0.81 | HPGD (0.69) | NPSR1HPGDALDH1A1KDM4ERCE1 | |
| SCHEMBL2938380 | 0.81 | KMT2A (0.69) | NPSR1HPGDALDH1A1KDM4ERCE1 | |
| SCHEMBL4576228 | 0.80 | HDAC3 (0.50) | HDAC1 | |
| SCHEMBL5527432 | 0.80 | KMT2A (0.60) | NPSR1HPGDALDH1A1KDM4ERCE1 | |
| SCHEMBL4018757 | 0.80 | NPSR1 (0.59) | NPSR1HPGDALDH1A1KDM4ERCE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1673085-A4 | C-MET MODULATORS AND METHODS OF USE | EXELIXIS INC (US) | 2008-12-10 | — | — | EP | claimed |
| EP-1673085-A2 | C-MET MODULATORS AND METHODS OF USE | Exelixis, Inc. (US) | 2006-06-28 | — | — | EP | claimed |
| WO-2005030140-A2 | C-MET MODULATORS AND METHODS OF USE | EXELIXIS, INC. (US) | 2005-04-07 | — | — | WO | claimed |
| EP-2213661-B1 | c-Met Modulators and Methods of Use | EXELIXIS INC (US) | 2011-07-20 | — | — | EP | disclosed |
| EP-1673085-A4 | C-MET MODULATORS AND METHODS OF USE | EXELIXIS INC (US) | 2008-12-10 | — | — | EP | disclosed |
| EP-1673085-A2 | C-MET MODULATORS AND METHODS OF USE | Exelixis, Inc. (US) | 2006-06-28 | — | — | EP | disclosed |
| WO-2005030140-A2 | C-MET MODULATORS AND METHODS OF USE | EXELIXIS, INC. (US) | 2005-04-07 | — | — | WO | disclosed |