SCHEMBL4576594

SCHEMBL4576594

NC(=O)C(=O)NCc1cc(F)cc(C(F)(F)F)c1

nearest known ligand 0.48

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 8/20 0.48
ALDH1A1 P00352 2/20 0.48
MTOR P42345 2/20 0.48
HTT P42858 1/20 0.46
MLYCD O95822 1/20 0.46
NAMPT P43490 1/20 0.45
TACR1 P25103 3/20 0.45
F2 P00734 1/20 0.42
F10 P00742 1/20 0.42
P2RX1 P51575 1/20 0.42
TMPRSS4 Q9NRS4 1/20 0.42
LMNA P02545 2/20 0.42
TSHR P16473 2/20 0.42
KDM4E B2RXH2 1/20 0.42
VNN1 O95497 1/20 0.41
CCR2 P41597 1/20 0.41
MAPK1 P28482 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25779257 0.91 MTOR (0.55) MTORMLYCDTACR1P2RX1TMPRSS4
SCHEMBL25780518 0.84 P2RX1 (0.50) CYP3A4MTORMLYCDTACR1P2RX1
SCHEMBL25780520 0.84 MTOR (0.46) CYP3A4MTORMLYCDTACR1P2RX1
SCHEMBL25780517 0.84 MTOR (0.46) MTORMLYCDTACR1F2F10
SCHEMBL1274028 0.82 TACR1 (0.50) CYP3A4ALDH1A1MTORHTTMLYCD
SCHEMBL10310179 0.81 CYP3A4 (0.44) CYP3A4ALDH1A1MTORHTTMLYCD
SCHEMBL5670894 0.81 CYP3A4 (0.56) CYP3A4ALDH1A1MTORHTTMLYCD
Hydrochloric Acid SCHEMBL8004536 0.80 CYP3A4 (0.45) CYP3A4ALDH1A1MTORHTTMLYCD
SCHEMBL25780627 0.80 RXRA (0.45) MTORMLYCDTACR1P2RX1TMPRSS4
Hydrochloric Acid SCHEMBL8004530 0.79 MTOR (0.49) CYP3A4ALDH1A1MTORHTTMLYCD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1673085-A4 C-MET MODULATORS AND METHODS OF USE EXELIXIS INC (US) 2008-12-10 EP claimed
EP-1673085-A2 C-MET MODULATORS AND METHODS OF USE Exelixis, Inc. (US) 2006-06-28 EP claimed
WO-2005030140-A2 C-MET MODULATORS AND METHODS OF USE EXELIXIS, INC. (US) 2005-04-07 WO claimed
WO-2023118434-A1 PESTICIDALLY ACTIVE AMIDE COMPOUNDS GLOBACHEM NV (BE) 2023-06-29 WO disclosed