SCHEMBL4576648

SCHEMBL4576648

CCC(=O)[Si](C)(C)C

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14760146 0.86 ALDH1A1 (0.41)
SCHEMBL25364748 0.73 ALDH1A1 (0.37)
SCHEMBL28004468 0.73 TDP1 (0.37)
SCHEMBL14503602 0.73
SCHEMBL3144709 0.69
SCHEMBL25190012 0.69 TDP1 (0.33)
SCHEMBL25199497 0.69 TDP1 (0.33)
SCHEMBL14759971 0.69 ALDH1A1 (0.39)
SCHEMBL29013295 0.69 ALDH1A1 (0.39)
SCHEMBL8696362 0.69

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6194579-B1 PROVIDING QUANTITY OF 7-KETO CAMPTOTHECIN; SELECTIVELY SUBSTITUTING LEAVING GROUP AT C7 CARBON OF 7-KETO CAMPTOTHECIN; SELECTIVELY DERIVATIZING C7 CARBON BIONUMERIK PHARMACEUTICALS, INC. 2001-02-27 US claimed
CN-118159590-A Preparation of organosilicon compounds having carbinol functionality 陶氏环球技术有限责任公司 2024-06-07 CN disclosed
CN-118043331-A Preparation of amino-functional organosilicon compounds 陶氏环球技术有限责任公司 2024-05-14 CN disclosed
CN-118019748-A Preparation of imine-and primary amino-functional organosilicon compounds 陶氏环球技术有限责任公司 2024-05-10 CN disclosed
CN-118019747-A Preparation of propylimine-functionalized organosilicon compounds and primary aminopropyl-functionalized organosilicon compounds 陶氏环球技术有限责任公司 2024-05-10 CN disclosed
CN-116261565-A Preparation of organosilicon compounds having aldehyde functions 美国陶氏有机硅公司 2023-06-13 CN disclosed
CN-105980384-B Macrocyclic compounds having a heterocyclic P2' group as factor XIA inhibitors 百时美施贵宝公司 2019-11-15 CN disclosed
CN-105980384-A Macrocyclic compounds having a heterocyclic P2' group as factor XIA inhibitors 百时美施贵宝公司 2016-09-28 CN disclosed
EP-1140948-A4 CAMPTOTHECIN ANALOGS AND METHODS OF PREPARATION THEREOF UNIV PITTSBURGH (US) 2008-01-02 EP disclosed
CN-1219069-C Asymmetric synthesis method of antimer chiral silicon cyan aloohol UNIV HUANAN TECHNOLOGY (CN) 2005-09-14 CN disclosed
US-6743917-B2 7-(TRIALKYLSILYLALKYL)-CAMPTOTHECIN OF GIVEN FORMULA BY CYCLIZING A 4-HYDROXY-6-HALO,7-(TRIALKYLSILYLALKYL)-3,4,7,8-TETRAHYDRO-1H-PYRANO(3,4 -C)PYRIDIN-3,8-DIONE WITH AN ARYL ISONITRILE UNIVERSITY OF PITTSBURGH 2004-06-01 US disclosed
CN-1488760-A Asymmetric synthesis method of antimer chiral silicon cyan aloohol 华南理工大学 2004-04-14 CN disclosed
US-20020193598-A1 Camptothecin analogs and methods of preparation thereof NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2002-12-19 US disclosed
EP-1140948-A1 CAMPTOTHECIN ANALOGS AND METHODS OF PREPARATION THEREOF UNIVERSITY OF PITTSBURGH (US) 2001-10-10 EP disclosed
US-6136978-A CYCLIZING SILYL COMPOUND WITH ARYL ISONITRILE COMPOUND TO FORM SILYL CAMPTOTHECIN DERIVATIVE UNIVERSITY OF PITTSBURGH (US) 2000-10-24 US disclosed
WO-2000035924-A1 CAMPTOTHECIN ANALOGS AND METHODS OF PREPARATION THEREOF UNIVERSITY OF PITTSBURGH (US) 2000-06-22 WO disclosed
EP-0109617-A1 Positive type, radiation-sensitive organic polymer materials HITACHI, LTD. (JP) 1984-05-30 EP disclosed
US-4135045-A PROCESS FOR POLYMERIZATION OF OLEFINS AND CATALYST COMPOSITION THEREFOR MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) 1979-01-16 US disclosed
US-4048415-A TITANIUM-ALUMINUM COORDINATION CATALYSTS MITSUI PETROCHEMICAL INDUSTRIES LTD. (JA) 1977-09-13 US disclosed