Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 10/20 | 0.60 |
| ▸ | CCR3 | P51677 | 4/20 | 0.53 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.52 |
| ▸ | CCR2 | P41597 | 1/20 | 0.52 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.52 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.50 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.50 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.50 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.50 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.50 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.50 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.49 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.49 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.49 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4577575 | 0.92 | GRIN2B (0.55) | GRIN2BCCR3GRIN1GRIN2DGRIN3B | |
| SCHEMBL4577779 | 0.90 | CCR3 (0.64) | GRIN2BCCR3ROCK2CCR2ROCK1 | |
| SCHEMBL4579190 | 0.82 | CCR3 (0.62) | GRIN2BCCR3ROCK2CCR2ROCK1 | |
| SCHEMBL4578305 | 0.82 | CHRNB2 (0.69) | GRIN2BCCR3ROCK2CCR2ROCK1 | |
| SCHEMBL4576692 | 0.81 | GRIN1 (0.74) | GRIN2BGRIN1GRIN2DGRIN3BGRIN2A | |
| SCHEMBL27590237 | 0.81 | GRIN1 (0.52) | GRIN2BCCR3GRIN1GRIN2DGRIN3B | |
| Hydrochloric Acid SCHEMBL4578053 | 0.80 | GRIN1 (0.72) | GRIN2BGRIN1GRIN2DGRIN3BGRIN2A | |
| SCHEMBL4576904 | 0.79 | GRIN1 (0.75) | GRIN2BGRIN1GRIN2DGRIN3BGRIN2A | |
| SCHEMBL4420713 | 0.78 | GRIN1 (0.75) | GRIN2BGRIN1GRIN2DGRIN3BGRIN2A | |
| SCHEMBL4577518 | 0.78 | GRIN2B (0.69) | GRIN2BCCR3GRIN1GRIN2DGRIN3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7435744-B2 | Piperidine derivatives as NMDA receptor antagonists | GEDEON RICHTER VEGYESZETI GYAR RT (HU) | 2008-10-14 | — | — | US | disclosed |
| EP-1409477-B1 | PIPERIDINE DERIVATIVES AS NMDA RECEPTOR ANTAGONISTS | RICHTER GEDEON NYRT (HU) | 2008-09-17 | — | — | EP | disclosed |
| US-20040157886-A1 | Piperdine derivatives as NMDA receptor antagonists | UCB Biopharma SRL (BE) | 2004-08-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040157886-A1 | Piperdine derivatives as NMDA receptor antagonists | GRIN1, GRIN2D, GRIN2C | GRIN2B 7/4885CCR3 672/4885ROCK2 4291/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.