Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.68 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.68 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.68 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | KYNU | Q16719 | 2/20 | 0.43 |
| ▸ | KIF11 | P52732 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | ALPI | P09923 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | XIAP | P98170 | 1/20 | 0.41 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.41 |
| ▸ | KMO | O15229 | 3/20 | 0.40 |
| ▸ | SLC1A3 | P43003 | 2/20 | 0.40 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.40 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.40 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.40 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Kynurenine SCHEMBL29349989 | 0.92 | KDM4E (0.64) | KDM4EHIF1ATDP1KYNUGAA | |
| L-Kynurenine SCHEMBL29396313 | 0.92 | KDM4E (0.64) | KDM4EHIF1ATDP1KYNUGAA | |
| Kynurenine SCHEMBL20874 | 0.92 | KDM4E (0.64) | KDM4EHIF1ATDP1KYNUGAA | |
| L-Kynurenine SCHEMBL13969610 | 0.92 | KDM4E (0.64) | KDM4EHIF1ATDP1KYNUGAA | |
| L-Kynurenine SCHEMBL20875 | 0.92 | KDM4E (0.64) | KDM4EHIF1ATDP1KYNUGAA | |
| Kynurenine SCHEMBL2181581 | 0.92 | KDM4E (0.64) | KDM4EHIF1ATDP1KYNUGAA | |
| L-Kynurenine SCHEMBL288989 | 0.92 | KDM4E (0.64) | KDM4EHIF1ATDP1KYNUGAA | |
| Kynurenine SCHEMBL288988 | 0.92 | KDM4E (0.64) | KDM4EHIF1ATDP1KYNUGAA | |
| L-Kynurenine SCHEMBL29415716 | 0.92 | KDM4E (0.64) | KDM4EHIF1ATDP1KYNUGAA | |
| Kynurenine SCHEMBL288254 | 0.92 | KDM4E (0.64) | KDM4EHIF1ATDP1KYNUGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1311299-A4 | METHOD FOR THE IDENTIFICATION OF AGENTS THAT INHIBIT OR PROMOTE CATARACTS AND USES THEREOF | GEN HOSPITAL CORP (US) | 2008-01-02 | — | — | EP | disclosed |
| US-7166472-B2 | Method for the identification of agents that inhibit or promote cataracts and uses thereof | THE GENERAL HOSPITAL CORPORATION (US) | 2007-01-23 | — | — | US | disclosed |
| US-20050084918-A1 | Method for the identification of agents that inhibit or promote cataracts and uses thereof | BUSH ASHLEY I (US) | 2005-04-21 | — | — | US | disclosed |
| EP-1311299-A1 | METHOD FOR THE IDENTIFICATION OF AGENTS THAT INHIBIT OR PROMOTE CATARACTS AND USES THEREOF | THE GENERAL HOSPITAL CORPORATION (US) | 2003-05-21 | — | — | EP | disclosed |
| WO-2002015942-A1 | METHOD FOR THE IDENTIFICATION OF AGENTS THAT INHIBIT OR PROMOTE CATARACTS AND USES THEREOF | THE GENERAL HOSPITAL CORPORATION (US) | 2002-02-28 | — | — | WO | disclosed |