SCHEMBL4577466

SCHEMBL4577466

CC(C)(C)N1CC(C(=O)N2CCC(c3ccc(Cl)cc3CCNC(=O)C3CCC3)CC2)C(c2ccc(F)cc2F)C1

nearest known ligand 0.64

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
MC4R P32245 9/20 0.64
MC3R P41968 3/20 0.64
MC5R P33032 2/20 0.58
PRCP P42785 11/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4576689 0.95 MC4R (0.58) MC4RMC3RMC5RPRCP
SCHEMBL4576827 0.90 MC4R (0.65) MC4RMC3RMC5RPRCP
SCHEMBL5617401 0.86 MC4R (0.72) MC4RMC3RMC5RPRCP
SCHEMBL4577263 0.85 MC4R (0.63) MC4RMC3RMC5RPRCP
SCHEMBL8269076 0.85 MC4R (0.71) MC4RMC3RMC5RPRCP
SCHEMBL4576351 0.84 MC4R (0.59) MC4RMC3RMC5RPRCP
SCHEMBL6240837 0.84 MC4R (0.67) MC4RMC3RMC5RPRCP
SCHEMBL6240843 0.84 MC4R (0.67) MC4RMC3RMC5RPRCP
SCHEMBL5227884 0.83 MC4R (0.67) MC4RMC3RMC5RPRCP
SCHEMBL4577461 0.83 MC4R (0.73) MC4RMC3RMC5RPRCP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1534074-A4 COMBINATION THERAPY FOR THE TREATMENT OF OBESITY MERCK & CO INC (US) 2008-01-09 EP claimed
EP-1799241-A2 COMBINATION THERAPY FOR THE TREATMENT OF OBESITY Merck & Co., Inc. (US) 2007-06-27 EP claimed
WO-2006036770-A2 COMBINATION THERAPY FOR THE TREATMENT OF OBESITY MERCK & CO., INC. (US) 2006-04-06 WO claimed
EP-1534074-A2 COMBINATION THERAPY FOR THE TREATMENT OF OBESITY Merck & Co., Inc. (US) 2005-06-01 EP claimed
WO-2004009015-A2 COMBINATION THERAPY FOR THE TREATMENT OF OBESITY MERCK & CO., INC. (US) 2004-01-29 WO claimed
EP-1534074-A4 COMBINATION THERAPY FOR THE TREATMENT OF OBESITY MERCK & CO INC (US) 2008-01-09 EP disclosed
EP-1807102-A2 COMPOSITIONS AND METHODS FOR THE TREATMENT OF OBESITY AND SEXUAL DYSFUNCTION Merck & Co., Inc. (US) 2007-07-18 EP disclosed
EP-1799241-A2 COMBINATION THERAPY FOR THE TREATMENT OF OBESITY Merck & Co., Inc. (US) 2007-06-27 EP disclosed
WO-2006049933-A2 COMPOSITIONS AND METHODS FOR THE TREATMENT OF OBESITY AND SEXUAL DYSFUNCTION MERCK & CO., INC. (US) 2006-05-11 WO disclosed
WO-2006036770-A2 COMBINATION THERAPY FOR THE TREATMENT OF OBESITY MERCK & CO., INC. (US) 2006-04-06 WO disclosed
EP-1534074-A2 COMBINATION THERAPY FOR THE TREATMENT OF OBESITY Merck & Co., Inc. (US) 2005-06-01 EP disclosed
WO-2004009015-A2 COMBINATION THERAPY FOR THE TREATMENT OF OBESITY MERCK & CO., INC. (US) 2004-01-29 WO disclosed