SCHEMBL4576351

SCHEMBL4576351

CCC(=O)NCCc1cc(F)ccc1C1CCN(C(=O)C2CN(C(C)(C)C)CC2c2ccc(F)cc2F)CC1

nearest known ligand 0.59

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
MC4R P32245 7/20 0.59
MC3R P41968 2/20 0.59
PRCP P42785 13/20 0.58
MC5R P33032 1/20 0.54
MC1R Q01726 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4576827 0.95 MC4R (0.65) MC4RMC3RPRCPMC5R
SCHEMBL4577263 0.92 MC4R (0.63) MC4RMC3RPRCPMC5R
SCHEMBL4576689 0.89 MC4R (0.58) MC4RMC3RPRCPMC5R
SCHEMBL4577466 0.84 MC4R (0.64) MC4RMC3RPRCPMC5R
SCHEMBL4577231 0.83 PRCP (0.63) MC4RMC3RPRCP
SCHEMBL5617401 0.82 MC4R (0.72) MC4RMC3RPRCPMC5R
SCHEMBL4576342 0.82 MC4R (0.68) MC4RMC3RPRCPMC5R
SCHEMBL4577262 0.82 PRCP (0.58) MC4RMC3RPRCP
SCHEMBL5608656 0.81 MC4R (0.68) MC4RMC3RPRCPMC5R
SCHEMBL5227884 0.80 MC4R (0.67) MC4RMC3RPRCPMC5R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1534074-A4 COMBINATION THERAPY FOR THE TREATMENT OF OBESITY MERCK & CO INC (US) 2008-01-09 EP claimed
EP-1799241-A2 COMBINATION THERAPY FOR THE TREATMENT OF OBESITY Merck & Co., Inc. (US) 2007-06-27 EP claimed
WO-2006036770-A2 COMBINATION THERAPY FOR THE TREATMENT OF OBESITY MERCK & CO., INC. (US) 2006-04-06 WO claimed
EP-1534074-A2 COMBINATION THERAPY FOR THE TREATMENT OF OBESITY Merck & Co., Inc. (US) 2005-06-01 EP claimed
WO-2004009015-A2 COMBINATION THERAPY FOR THE TREATMENT OF OBESITY MERCK & CO., INC. (US) 2004-01-29 WO claimed
EP-1534074-A4 COMBINATION THERAPY FOR THE TREATMENT OF OBESITY MERCK & CO INC (US) 2008-01-09 EP disclosed
EP-1807102-A2 COMPOSITIONS AND METHODS FOR THE TREATMENT OF OBESITY AND SEXUAL DYSFUNCTION Merck & Co., Inc. (US) 2007-07-18 EP disclosed
EP-1799241-A2 COMBINATION THERAPY FOR THE TREATMENT OF OBESITY Merck & Co., Inc. (US) 2007-06-27 EP disclosed
WO-2006049933-A2 COMPOSITIONS AND METHODS FOR THE TREATMENT OF OBESITY AND SEXUAL DYSFUNCTION MERCK & CO., INC. (US) 2006-05-11 WO disclosed
WO-2006036770-A2 COMBINATION THERAPY FOR THE TREATMENT OF OBESITY MERCK & CO., INC. (US) 2006-04-06 WO disclosed
EP-1534074-A2 COMBINATION THERAPY FOR THE TREATMENT OF OBESITY Merck & Co., Inc. (US) 2005-06-01 EP disclosed
WO-2004009015-A2 COMBINATION THERAPY FOR THE TREATMENT OF OBESITY MERCK & CO., INC. (US) 2004-01-29 WO disclosed