Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 6/20 | 0.49 |
| ▸ | OPRM1 | P35372 | 6/20 | 0.49 |
| ▸ | OPRD1 | P41143 | 6/20 | 0.49 |
| ▸ | OPRK1 | P41145 | 6/20 | 0.49 |
| ▸ | OPRL1 | P41146 | 6/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.45 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.45 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.45 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.45 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 3/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3834657 | 0.80 | OPRM1 (0.45) | CYP3A4OPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL13317173 | 0.79 | OPRM1 (0.51) | CYP3A4OPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL2142315 | 0.79 | OPRM1 (0.51) | CYP3A4OPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL69083 | 0.79 | OPRM1 (0.56) | CYP3A4OPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL1742229 | 0.78 | OPRM1 (0.71) | CYP3A4OPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL1489316 | 0.78 | OPRM1 (0.50) | CYP3A4OPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL1488335 | 0.77 | CYP3A4 (0.53) | CYP3A4OPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL7691375 | 0.77 | OPRL1 (0.60) | CYP3A4OPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL3224569 | 0.75 | OPRM1 (0.48) | CYP3A4OPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL10569014 | 0.75 | CYP3A4 (0.54) | CYP3A4OPRM1OPRD1OPRK1OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111643496-A | Methods of using MEK inhibitors | 埃克塞利希斯股份有限公司 | 2020-09-11 | — | — | CN | disclosed |
| CN-105106199-A | Methods of using MEK inhibitors | EXELIXIS INC | 2015-12-02 | — | — | CN | disclosed |
| EP-1934174-A1 | AZETIDINES AS MEK INHIBITORS FOR THE TREATMENT OF PROLIFERATIVE DISEASES | Exelixis, Inc. (US) | 2008-06-25 | — | — | EP | disclosed |
| WO-2007044515-A1 | AZETIDINES AS MEK INHIBITORS FOR THE TREATMENT OF PROLIFERATIVE DISEASES | EXELIXIS, INC. (US) | 2007-04-19 | — | — | WO | disclosed |