SCHEMBL4579109

SCHEMBL4579109

CCOC(=O)C(C#N)c1ccccc1C

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GAA P10253 4/20 0.58
MEN1 O00255 3/20 0.58
KMT2A Q03164 3/20 0.58
SMN1; SMN2 Q16637 2/20 0.58
MAPT P10636 2/20 0.43
NPSR1 Q6W5P4 2/20 0.43
ALDH1A1 P00352 2/20 0.43
LMNA P02545 1/20 0.43
TDP1 Q9NUW8 3/20 0.42
PIN1 Q13526 1/20 0.41
L3MBTL1 Q9Y468 3/20 0.41
TSHR P16473 2/20 0.41
NPC1 O15118 1/20 0.41
DHODH Q02127 1/20 0.40
CASP1 P29466 2/20 0.39
KDM4E B2RXH2 1/20 0.39
MMP13 P45452 1/20 0.39
CASP7 P55210 1/20 0.39
ESR1 P03372 1/20 0.39
MMP8 P22894 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17843998 0.87 SMN1; SMN2 (0.58) GAAMEN1KMT2ASMN1; SMN2MAPT
SCHEMBL30168361 0.87 SMN1; SMN2 (0.58) GAAMEN1KMT2ASMN1; SMN2MAPT
SCHEMBL5568981 0.86 SMN1; SMN2 (0.57) GAAMEN1KMT2ASMN1; SMN2MAPT
SCHEMBL16466618 0.85 KMT2A (0.44) GAAMEN1KMT2ASMN1; SMN2MAPT
SCHEMBL7465410 0.84 MEN1 (0.56) GAAMEN1KMT2ASMN1; SMN2MAPT
SCHEMBL6137068 0.84 SMN1; SMN2 (0.56) GAAMEN1KMT2ASMN1; SMN2MAPT
SCHEMBL6522396 0.84 SMN1; SMN2 (0.56) GAAMEN1KMT2ASMN1; SMN2MAPT
SCHEMBL22904151 0.81 MEN1 (0.47) GAAMEN1KMT2ASMN1; SMN2MAPT
SCHEMBL17844019 0.81 SMN1; SMN2 (0.49) GAAMEN1KMT2ASMN1; SMN2MAPT
SCHEMBL29226191 0.81 KMT2A (0.52) GAAMEN1KMT2ASMN1; SMN2MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 337 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2837660-B1 CURABLE COMPOSITION, AND CURED SYNTHETIC RESIN USING SAME UNIV MIE (JP) 2021-07-14 EP disclosed
US-9376525-B2 Curable composition, and cured synthetic resin using same MIE UNIVERSITY (JP) 2016-06-28 US disclosed
US-20150099849-A1 CURABLE COMPOSITION, AND CURED SYNTHETIC RESIN USING SAME MIE UNIVERSITY (JP) 2015-04-09 US disclosed
EP-2837660-A1 CURABLE COMPOSITION, AND CURED SYNTHETIC RESIN USING SAME Mie University (JP) 2015-02-18 EP disclosed
US-7414146-B2 Imaging element containing a blocked photographically useful compound CARESTREAM HEALTH, INC. (US) 2008-08-19 US disclosed
US-7312335-B2 Asymmetric Michael and Aldol additions using bifunctional cinchona-alkaloid-based catalysts BRANDEIS UNIVERSITY (US) 2007-12-25 US disclosed
US-7312335-B2 Asymmetric Michael and Aldol additions using bifunctional cinchona-alkaloid-based catalysts BRANDEIS UNIVERSITY (US) 2007-12-25 US disclosed
EP-1315035-B1 Core/shell silver donors for photothermographic systems comprising an oxidatively less reactive shell EASTMAN KODAK CO (US) 2007-03-28 EP disclosed
EP-1380890-B1 High speed thermally developable imaging materials and methods of using the same EASTMAN KODAK CO (US) 2007-01-17 EP disclosed
US-7157219-B2 Photothermographic materials containing silver halide sensitized with combination of compounds EASTMAN KODAK COMPANY (US) 2007-01-02 US disclosed
EP-0639791-A2 Photothermographic elements containing photographically useful compounds with silyl blocking groups MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1995-02-22 EP disclosed
US-5382504-A Negative photographic element MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1995-01-17 US disclosed
US-5380644-A Fluorinated acrylic terpolymer surfactant for coating MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1995-01-10 US disclosed
US-5370988-A A silver halide emulsions consisting of a reducible silver compound, reducing agents, a binder and a substituted hydroxyphenyl compound; shelf life, stability, high density images, sharpness MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1994-12-06 US disclosed
US-5369000-A Bromoalkyl sulfone antifogging agents MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1994-11-29 US disclosed
WO-1994025900-A1 PHOTOTHERMOGRAPHIC ELEMENTS MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1994-11-10 WO disclosed
EP-0622666-A1 Post-processing stabilizers for photothermographic articles MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1994-11-02 EP disclosed
US-5358843-A Deblocking with fluoride ions MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1994-10-25 US disclosed
US-5350669-A Silver-carboxylate/1,2-diazine compounds as silver sources in photothermographic and thermographic elements MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1994-09-27 US disclosed
EP-0599463-A2 High speed, dry processed printing plate construction MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1994-06-01 EP disclosed