Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | BRAF | P15056 | 1/20 | 0.39 |
| ▸ | AR | P10275 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | TBXA2R | P21731 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22904598 | 0.88 | MEN1 (0.45) | MEN1KMT2AGAASMN1; SMN2TDP1 | |
| SCHEMBL22904394 | 0.88 | KMT2A (0.45) | MEN1KMT2AGAASMN1; SMN2TDP1 | |
| SCHEMBL11124907 | 0.86 | MEN1 (0.45) | MEN1KMT2AGAASMN1; SMN2TDP1 | |
| SCHEMBL22904531 | 0.82 | KMT2A (0.42) | MEN1KMT2AGAASMN1; SMN2TDP1 | |
| SCHEMBL4579109 | 0.81 | GAA (0.58) | MEN1KMT2AGAASMN1; SMN2TDP1 | |
| SCHEMBL22904600 | 0.81 | VEGFA (0.44) | MEN1KMT2AGAASMN1; SMN2MAPT | |
| SCHEMBL1366941 | 0.80 | KMT2A (0.48) | MEN1KMT2AGAASMN1; SMN2TDP1 | |
| SCHEMBL30708366 | 0.80 | KMT2A (0.48) | MEN1KMT2AGAASMN1; SMN2TDP1 | |
| SCHEMBL22904512 | 0.80 | SMN1; SMN2 (0.48) | MEN1KMT2AGAASMN1; SMN2TDP1 | |
| SCHEMBL6137068 | 0.79 | SMN1; SMN2 (0.56) | MEN1KMT2AGAASMN1; SMN2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021011631-A1 | FUSED-GLUTARIMIDE CRBN LIGANDS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2021-01-21 | — | — | WO | disclosed |