Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFE2L2 | Q16236 | 13/20 | 0.62 |
| ▸ | RELA | Q04206 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.39 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9488120 | 1.00 | NFE2L2 (0.62) | NFE2L2RELANPC1PKMNFKB1 | |
| SCHEMBL9875741 | 0.78 | NFE2L2 (0.62) | NFE2L2RELANPC1PKMNFKB1 | |
| SCHEMBL15050711 | 0.78 | NFE2L2 (0.62) | NFE2L2RELANPC1PKMNFKB1 | |
| SCHEMBL9723366 | 0.78 | NFE2L2 (0.62) | NFE2L2RELANPC1PKMNFKB1 | |
| SCHEMBL320615 | 0.78 | NFE2L2 (0.62) | NFE2L2RELANPC1PKMNFKB1 | |
| SCHEMBL24709985 | 0.78 | NFE2L2 (0.62) | NFE2L2RELANPC1PKMNFKB1 | |
| SCHEMBL4090323 | 0.78 | NFE2L2 (0.62) | NFE2L2RELANPC1PKMNFKB1 | |
| SCHEMBL14416278 | 0.78 | NFE2L2 (0.62) | NFE2L2RELANPC1PKMNFKB1 | |
| SCHEMBL7292536 | 0.78 | NFE2L2 (0.62) | NFE2L2RELANPC1PKMNFKB1 | |
| SCHEMBL12426131 | 0.78 | NFE2L2 (0.62) | NFE2L2RELANPC1PKMNFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1963260-A1 | PROCESS FOR THE PRODUCTION OF EZETIMIBE AND INTERMEDIATES USED IN THIS PROCES | Richter Gedeon NYRT (HU) | 2008-09-03 | — | — | EP | disclosed |
| WO-2007072088-A1 | PROCESS FOR THE PRODUCTION OF EZETIMIBE AND INTERMEDIATES USED IN THIS PROCES | RICHTER GEDEON NYRT. (HU) | 2007-06-28 | — | — | WO | disclosed |
| EP-0143952-B1 | SUBSTITUTED CINNAMYL-2,3-DIHYDROBENZOPYRANS AND CINNAMYLPHENOLS USEFUL AS ANTI-INFLAMMATORY AGENTS | MERCK & CO. INC. (US) | 1993-01-13 | — | — | EP | disclosed |
| US-4778818-A | VISION AND SKIN DISORDERS | MERCK & CO., INC. (US) | 1988-10-18 | — | — | US | disclosed |
| US-4686235-A | TOPICAL | MERCK & CO., INC. (US) | 1987-08-11 | — | — | US | disclosed |
| US-4537903-A | Substituted cinnamyl-2,3-dihydrobenzofuran and analogs useful as anti-inflammatory agents | MERCK & CO., INC. (US) | 1985-08-27 | — | — | US | disclosed |
| EP-0143952-A1 | Substituted cinnamyl-2,3-dihydrobenzopyrans and cinnamylphenols useful as anti-inflammatory agents | MERCK & CO. INC. (US) | 1985-06-12 | — | — | EP | disclosed |