Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 15/20 | 0.59 |
| ▸ | HTR2A | P28223 | 10/20 | 0.59 |
| ▸ | DRD2 | P14416 | 12/20 | 0.57 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.54 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4580911 | 0.89 | DRD4 (0.60) | DRD4HTR2ADRD2CHRM4 | |
| SCHEMBL4578392 | 0.85 | MCHR1 (0.73) | DRD4HTR2ADRD2CHRM4MCHR1 | |
| SCHEMBL5166477 | 0.82 | CHRM4 (0.55) | DRD4HTR2ADRD2CHRM4MCHR1 | |
| SCHEMBL4579458 | 0.81 | DRD4 (0.57) | DRD4HTR2ADRD2CHRM4 | |
| SCHEMBL4579564 | 0.80 | HDAC1 (0.64) | DRD4HTR2ADRD2CHRM4MCHR1 | |
| SCHEMBL1067900 | 0.79 | CHRM4 (0.55) | DRD4HTR2ADRD2CHRM4MCHR1 | |
| SCHEMBL4578591 | 0.79 | DRD4 (0.42) | DRD4HTR2ADRD2CHRM4MCHR1 | |
| SCHEMBL4580616 | 0.79 | HDAC1 (0.63) | HDAC1 | |
| SCHEMBL4578738 | 0.79 | HDAC1 (0.63) | HDAC1 | |
| SCHEMBL4578742 | 0.79 | HDAC1 (0.63) | HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2007720-B1 | BENZAMIDE DERIVATIVES AS INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE INC (CA) | 2013-12-25 | — | — | EP | disclosed |
| US-8598168-B2 | Inhibitors of histone deacetylase | METHYLGENE INC. (CA) | 2013-12-03 | — | — | US | disclosed |
| US-20080132503-A1 | Inhibitors of Histone Deacetylase | METHYLGENE INC. (CA) | 2008-06-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080132503-A1 | Inhibitors of Histone Deacetylase | HDAC1, HDAC5, HDAC3 | DRD4 4581/4885HTR2A 4048/4885DRD2 4756/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.