Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 18/20 | 0.57 |
| ▸ | DRD2 | P14416 | 15/20 | 0.57 |
| ▸ | HTR2A | P28223 | 12/20 | 0.57 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4580911 | 0.83 | DRD4 (0.60) | DRD4DRD2HTR2ACHRM4 | |
| SCHEMBL4579442 | 0.82 | DRD4 (0.54) | DRD4DRD2HTR2A | |
| SCHEMBL4578949 | 0.81 | HDAC1 (0.58) | DRD4DRD2HTR2A | |
| SCHEMBL4578946 | 0.81 | HDAC1 (0.58) | DRD4DRD2HTR2A | |
| SCHEMBL4579575 | 0.81 | DRD4 (0.59) | DRD4DRD2HTR2ACHRM4 | |
| SCHEMBL4790044 | 0.81 | DRD4 (0.53) | DRD4DRD2HTR2A | |
| SCHEMBL4789471 | 0.78 | DRD4 (0.48) | DRD4DRD2HTR2A | |
| SCHEMBL14155917 | 0.78 | DRD4 (0.49) | DRD4DRD2HTR2A | |
| SCHEMBL1067900 | 0.74 | CHRM4 (0.55) | DRD4DRD2HTR2ACHRM4 | |
| SCHEMBL8711816 | 0.74 | DRD4 (1.00) | DRD4DRD2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8598168-B2 | Inhibitors of histone deacetylase | METHYLGENE INC. (CA) | 2013-12-03 | — | — | US | disclosed |
| US-20080132503-A1 | Inhibitors of Histone Deacetylase | METHYLGENE INC. (CA) | 2008-06-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080132503-A1 | Inhibitors of Histone Deacetylase | HDAC1, HDAC5, HDAC3 | DRD4 4581/4885DRD2 4756/4885HTR2A 4048/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.