Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 1/20 | 0.57 |
| ▸ | KDR | P35968 | 12/20 | 0.54 |
| ▸ | HDAC3 | O15379 | 7/20 | 0.54 |
| ▸ | HDAC4 | P56524 | 7/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 7/20 | 0.54 |
| ▸ | HDAC7 | Q8WUI4 | 7/20 | 0.54 |
| ▸ | HDAC2 | Q92769 | 7/20 | 0.54 |
| ▸ | HDAC10 | Q969S8 | 7/20 | 0.54 |
| ▸ | HDAC11 | Q96DB2 | 7/20 | 0.54 |
| ▸ | HDAC8 | Q9BY41 | 7/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 7/20 | 0.54 |
| ▸ | HDAC9 | Q9UKV0 | 7/20 | 0.54 |
| ▸ | HDAC5 | Q9UQL6 | 7/20 | 0.54 |
| ▸ | FLT1 | P17948 | 3/20 | 0.51 |
| ▸ | FBP1 | P09467 | 1/20 | 0.50 |
| ▸ | EGFR | P00533 | 6/20 | 0.49 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.48 |
| ▸ | FLT4 | P35916 | 2/20 | 0.48 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.48 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5091094 | 0.91 | KDR (0.62) | KDRFLT1EGFRFGFR1FLT4 | |
| SCHEMBL4579621 | 0.89 | FBP1 (0.50) | SRCKDRFBP1EGFRABCG2 | |
| SCHEMBL4578059 | 0.89 | KDR (0.50) | SRCKDRHDAC3HDAC4HDAC1 | |
| SCHEMBL4580086 | 0.86 | KDR (0.58) | SRCKDRHDAC3HDAC4HDAC1 | |
| SCHEMBL4576907 | 0.86 | FBP1 (0.60) | KDRFBP1EGFRFLT4 | |
| SCHEMBL4580113 | 0.86 | KDR (0.69) | SRCKDRHDAC3HDAC4HDAC1 | |
| SCHEMBL4578020 | 0.85 | EGFR (0.50) | KDRFLT1FBP1EGFRFGFR1 | |
| SCHEMBL4578322 | 0.85 | EGFR (0.62) | SRCKDRFBP1EGFRABCG2 | |
| SCHEMBL4576844 | 0.84 | EGFR (0.52) | FBP1EGFRABCG2 | |
| SCHEMBL4578447 | 0.84 | EGFR (0.55) | SRCKDRFLT1FBP1EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8846699-B2 | Quinazoline derivatives as a multiplex inhibitor and method for the preparation thereof | HANMI PHARM. CO., LTD. (KR) | 2014-09-30 | — | — | US | disclosed |
| EP-1951686-B1 | QUINAZOLINE DERIVATIVES AS A MULTIPLEX INHIBITOR AND METHOD FOR THE PREPARATION THEREOF | HANMI PHARM IND CO LTD (KR) | 2013-04-03 | — | — | EP | disclosed |
| US-20080318950-A1 | Quinazoline Derivatives as a Multiplex Inhibitor and Method For the Preparation Thereof | HANMI PHARM. CO., LTD (KR) | 2008-12-25 | — | — | US | disclosed |
| EP-1951686-A1 | QUINAZOLINE DERIVATIVES AS A MULTIPLEX INHIBITOR AND METHOD FOR THE PREPARATION THEREOF | Hanmi Pharm. Co., Ltd. (KR) | 2008-08-06 | — | — | EP | disclosed |
| WO-2007055514-A1 | QUINAZOLINE DERIVATIVES AS A MULTIPLEX INHIBITOR AND METHOD FOR THE PREPARATION THEREOF | HANMI PHARM. CO., LTD. (KR) | 2007-05-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080318950-A1 | Quinazoline Derivatives as a Multiplex Inhibitor and Method For the Preparation Thereof | ABL1, JAK1, BTK | SRC 82/4885KDR 1226/4885HDAC3 2303/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.