Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 7/20 | 0.45 |
| ▸ | HSP90AB1 | P08238 | 4/20 | 0.43 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.34 |
| ▸ | CHRNA10 | Q9GZZ6 | 1/20 | 0.34 |
| ▸ | CHRNA9 | Q9UGM1 | 1/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.31 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | CA7 | P43166 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4580729 | 0.82 | HSP90AA1 (0.39) | HSP90AA1HSP90AB1MAPK1OPRM1HDAC6 | |
| SCHEMBL4580945 | 0.82 | HSP90AA1 (0.34) | HSP90AA1HSP90AB1 | |
| SCHEMBL14291808 | 0.80 | HSP90AA1 (0.40) | HSP90AA1HSP90AB1 | |
| SCHEMBL4580384 | 0.76 | HSP90AA1 (0.36) | HSP90AA1HSP90AB1 | |
| SCHEMBL14291682 | 0.68 | HSP90AA1 (0.42) | HSP90AA1HSP90AB1CHRNA7CHRNA10CHRNA9 | |
| SCHEMBL1220930 | 0.63 | HSP90AA1 (0.62) | HSP90AA1HSP90AB1CYP11B2OPRM1 | |
| SCHEMBL1219206 | 0.62 | HSP90AA1 (1.00) | HSP90AA1HSP90AB1OPRM1HDAC1HDAC6 | |
| SCHEMBL1219767 | 0.62 | KMT2A (0.69) | HSP90AA1HSP90AB1 | |
| SCHEMBL4580741 | 0.62 | HSP90AA1 (0.58) | HSP90AA1HSP90AB1CYP11B2OPRM1 | |
| SCHEMBL1219306 | 0.62 | CA4 (0.67) | HSP90AA1HSP90AB1OPRM1CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080076813-A1 | Benzene, Pyridine, and Pyridazine Derivatives | SERENEX, INC. | 2008-03-27 | — | — | US | claimed |
| US-20080076813-A1 | Benzene, Pyridine, and Pyridazine Derivatives | SERENEX, INC. | 2008-03-27 | — | — | US | disclosed |
| US-20080076813-A1 | Benzene, Pyridine, and Pyridazine Derivatives | SERENEX, INC. | 2008-03-27 | — | — | US | disclosed |
| WO-2008024970-A2 | TETRAHYDROINDOLONE AND TETRAHYDROINDAZOLONE DERIVATIVES | SERENEX, INC. (US) | 2008-02-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080076813-A1 | Benzene, Pyridine, and Pyridazine Derivatives | MKI67, CCNB1, CCNB3 | HSP90AA1 2797/4885HSP90AB1 2208/4885CHRNA7 3039/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.