Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 9/20 | 0.58 |
| ▸ | HSP90AB1 | P08238 | 5/20 | 0.58 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4581710 | 0.82 | HSP90AA1 (0.46) | HSP90AA1HSP90AB1CYP11B2OPRM1KDM4E | |
| SCHEMBL4578947 | 0.82 | HSP90AA1 (0.44) | HSP90AA1HSP90AB1 | |
| SCHEMBL4580028 | 0.79 | HSP90AA1 (0.42) | HSP90AA1HSP90AB1 | |
| SCHEMBL4579946 | 0.78 | HSP90AA1 (0.43) | HSP90AA1HSP90AB1CYP11B2MAPTKDM4E | |
| SCHEMBL4580635 | 0.76 | HSP90AA1 (0.44) | HSP90AA1HSP90AB1 | |
| SCHEMBL4582516 | 0.76 | HSP90AA1 (0.56) | HSP90AA1HSP90AB1 | |
| SCHEMBL1219767 | 0.75 | KMT2A (0.69) | HSP90AA1HSP90AB1TP53KMT2AMAPT | |
| SCHEMBL4580956 | 0.75 | HSP90AA1 (0.66) | HSP90AA1HSP90AB1 | |
| SCHEMBL1220930 | 0.74 | HSP90AA1 (0.62) | HSP90AA1HSP90AB1CYP11B2TP53KMT2A | |
| SCHEMBL4581205 | 0.74 | HSP90AA1 (0.70) | HSP90AA1HSP90AB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080076813-A1 | Benzene, Pyridine, and Pyridazine Derivatives | SERENEX, INC. | 2008-03-27 | — | — | US | claimed |
| US-20080076813-A1 | Benzene, Pyridine, and Pyridazine Derivatives | SERENEX, INC. | 2008-03-27 | — | — | US | disclosed |
| US-20080076813-A1 | Benzene, Pyridine, and Pyridazine Derivatives | SERENEX, INC. | 2008-03-27 | — | — | US | disclosed |
| WO-2008024970-A2 | TETRAHYDROINDOLONE AND TETRAHYDROINDAZOLONE DERIVATIVES | SERENEX, INC. (US) | 2008-02-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080076813-A1 | Benzene, Pyridine, and Pyridazine Derivatives | MKI67, CCNB1, CCNB3 | HSP90AA1 2797/4885HSP90AB1 2208/4885CYP11B2 710/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.