Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 8/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HSP90AB1 | P08238 | 4/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | IDH1 | O75874 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4581710 | 0.83 | HSP90AA1 (0.46) | HSP90AA1HSP90AB1ALDH1A1SMN1; SMN2CYP11B2 | |
| SCHEMBL4581211 | 0.81 | CYP11B2 (0.41) | GAAMAPTCYP11B2ATMIDH1 | |
| SCHEMBL1221129 | 0.81 | HSP90AA1 (0.47) | HSP90AA1MAPK1HSP90AB1ALDH1A1MAPT | |
| SCHEMBL4580741 | 0.78 | HSP90AA1 (0.58) | HSP90AA1HSP90AB1ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL1219750 | 0.74 | HSP90AA1 (0.45) | HSP90AA1HSP90AB1ALDH1A1KDM4EHSD17B10 | |
| SCHEMBL1220958 | 0.74 | HSP90AA1 (0.44) | HSP90AA1HSP90AB1ALDH1A1MAPTKDM4E | |
| SCHEMBL1220546 | 0.73 | HSP90AA1 (0.45) | HSP90AA1HSP90AB1ALDH1A1MAPTKDM4E | |
| SCHEMBL1220917 | 0.72 | HSP90AA1 (0.44) | HSP90AA1HSP90AB1ALDH1A1KDM4EHSD17B10 | |
| SCHEMBL1219990 | 0.72 | HSP90AA1 (0.45) | HSP90AA1HSP90AB1ALDH1A1KDM4EHSD17B10 | |
| SCHEMBL1220437 | 0.71 | HSP90AA1 (0.47) | HSP90AA1HSP90AB1ALDH1A1MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080076813-A1 | Benzene, Pyridine, and Pyridazine Derivatives | SERENEX, INC. | 2008-03-27 | — | — | US | claimed |
| US-20080076813-A1 | Benzene, Pyridine, and Pyridazine Derivatives | SERENEX, INC. | 2008-03-27 | — | — | US | disclosed |
| US-20080076813-A1 | Benzene, Pyridine, and Pyridazine Derivatives | SERENEX, INC. | 2008-03-27 | — | — | US | disclosed |
| US-20080076813-A1 | Benzene, Pyridine, and Pyridazine Derivatives | SERENEX, INC. | 2008-03-27 | — | — | US | disclosed |
| WO-2008024970-A2 | TETRAHYDROINDOLONE AND TETRAHYDROINDAZOLONE DERIVATIVES | SERENEX, INC. (US) | 2008-02-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080076813-A1 | Benzene, Pyridine, and Pyridazine Derivatives | MKI67, CCNB1, CCNB3 | HSP90AA1 2797/4885MAPK1 1107/4885HSP90AB1 2208/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.