Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 11/20 | 0.73 |
| ▸ | HDAC1 | Q13547 | 11/20 | 0.73 |
| ▸ | HDAC3 | O15379 | 9/20 | 0.71 |
| ▸ | HDAC4 | P56524 | 8/20 | 0.71 |
| ▸ | HDAC7 | Q8WUI4 | 8/20 | 0.71 |
| ▸ | HDAC2 | Q92769 | 8/20 | 0.71 |
| ▸ | HDAC10 | Q969S8 | 8/20 | 0.71 |
| ▸ | HDAC11 | Q96DB2 | 8/20 | 0.71 |
| ▸ | HDAC8 | Q9BY41 | 8/20 | 0.71 |
| ▸ | HDAC9 | Q9UKV0 | 8/20 | 0.71 |
| ▸ | HDAC5 | Q9UQL6 | 8/20 | 0.71 |
| ▸ | PTPRC | P08575 | 3/20 | 0.60 |
| ▸ | PTPN13 | Q12923 | 1/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31635250 | 0.89 | PTPRC (0.65) | HDAC6HDAC1HDAC3HDAC4HDAC7 | |
| SCHEMBL313148 | 0.87 | HDAC4 (0.68) | HDAC6HDAC1HDAC3HDAC4HDAC7 | |
| SCHEMBL8409096 | 0.87 | HDAC6 (0.61) | HDAC6HDAC1HDAC3HDAC4HDAC7 | |
| SCHEMBL7368415 | 0.87 | HDAC1 (0.73) | HDAC6HDAC1HDAC3HDAC4HDAC7 | |
| SCHEMBL5278428 | 0.86 | HDAC6 (0.56) | HDAC6HDAC1HDAC3HDAC4HDAC7 | |
| SCHEMBL1067946 | 0.86 | HDAC6 (0.81) | HDAC6HDAC1HDAC3HDAC4HDAC7 | |
| SCHEMBL8409079 | 0.86 | HDAC6 (0.54) | HDAC6HDAC1HDAC3HDAC4HDAC7 | |
| SCHEMBL541048 | 0.85 | LMNA (0.68) | HDAC6HDAC1HDAC3HDAC4HDAC7 | |
| SCHEMBL6037980 | 0.85 | HDAC6 (0.74) | HDAC6HDAC1HDAC3HDAC4HDAC7 | |
| SCHEMBL6037928 | 0.85 | HDAC6 (0.79) | HDAC6HDAC1HDAC3HDAC4HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8598168-B2 | Inhibitors of histone deacetylase | METHYLGENE INC. (CA) | 2013-12-03 | — | — | US | disclosed |
| EP-2007720-A1 | BENZAMIDE DERIVATIVES AS INHIBITORS OF HISTONE DEACETYLASE | Methylgene, Inc. (CA) | 2008-12-31 | — | — | EP | disclosed |
| US-20080132503-A1 | Inhibitors of Histone Deacetylase | METHYLGENE INC. (CA) | 2008-06-05 | — | — | US | disclosed |
| US-20080132503-A1 | Inhibitors of Histone Deacetylase | METHYLGENE INC. (CA) | 2008-06-05 | — | — | US | disclosed |
| US-20080132503-A1 | Inhibitors of Histone Deacetylase | METHYLGENE INC. (CA) | 2008-06-05 | — | — | US | disclosed |
| WO-2007118137-A1 | BENZAMIDE DERIVATIVES AS INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE INC. (CA) | 2007-10-18 | — | — | WO | disclosed |
| WO-2007118137-A1 | BENZAMIDE DERIVATIVES AS INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE INC. (CA) | 2007-10-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080132503-A1 | Inhibitors of Histone Deacetylase | HDAC1, HDAC5, HDAC3 | HDAC6 6/4885HDAC1 1/4885HDAC3 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.