SCHEMBL4581458

SCHEMBL4581458

NS(=O)(=O)c1cc(F)c(F)c(F)c1F

nearest known ligand 0.54

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
CA1 P00915 15/20 0.54
CA2 P00918 15/20 0.54
CA12 O43570 4/20 0.54
CA7 P43166 3/20 0.54
CA13 Q8N1Q1 2/20 0.54
CA9 Q16790 4/20 0.40
APEX1 P27695 1/20 0.38
CYP2C19 P33261 1/20 0.38
CA4 P22748 1/20 0.38
CA6 P23280 1/20 0.38
CA5A P35218 1/20 0.38
CA14 Q9ULX7 1/20 0.38
CA5B Q9Y2D0 1/20 0.38
KDM4E B2RXH2 1/20 0.37
ALDH1A1 P00352 1/20 0.37
CYP1A2 P05177 1/20 0.36
PTGS2 P35354 1/20 0.36
PTGES2 Q9H7Z7 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29671276 1.00 CA1 (0.54) CA1CA2CA12CA7CA13
SCHEMBL1245850 0.80 CA1 (0.43) CA1CA2CA12CA7CA13
SCHEMBL31296417 0.79 CA1 (0.52) CA1CA2CA12CA7CA13
SCHEMBL2775483 0.79 CA1 (0.52) CA1CA2CA12CA7CA13
SCHEMBL4453156 0.78 CA1 (0.39) CA1CA2CA12CA7CA13
SCHEMBL29571087 0.78 CA1 (0.39) CA1CA2CA12CA7CA13
SCHEMBL1535900 0.76 CA12 (0.38) CA1CA2CA12CA7CA13
SCHEMBL1799529 0.76 PTGES2 (0.43) CA1CA2CA12CA7CA13
SCHEMBL7245664 0.76 CA12 (0.38) CA1CA2CA12CA7CA13
SCHEMBL29671274 0.76 CA12 (0.38) CA1CA2CA12CA7CA13

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1631995-A2 MANUFACTURE OF A POLYMER DEVICE CAMBRIDGE UNIVERSITY TECHNICAL SERVICES LIMITED (GB) 2006-03-08 EP claimed
WO-2004100282-A2 MANUFACTURE OF A POLYMER DEVICE CAMBRIDGE UNIVERSITY TECHNICAL SERVICES LIMITED (GB) 2004-11-18 WO claimed
US-12559454-B2 Benzenesulfonamide derivatives and uses thereof 2692372 ONTARIO, INC. (CA) 2026-02-24 US disclosed
US-20220281812-A1 BENZENESULFONAMIDE DERIVATIVES AND USES THEREOF 2692372 ONTARIO INC (CA) 2022-09-08 US disclosed
US-8530269-B2 Manufacture of a polymer device CAMBRIDGE ENTERPRISE LTD (GB) 2013-09-10 US disclosed
EP-1631995-B1 MANUFACTURE OF A POLYMER DEVICE CAMBRIDGE ENTPR LTD (GB) 2008-07-16 EP disclosed
US-20070172978-A1 Manufacture of a polymer device CAMBRIDGE UNIVERSITY TECHNICAL SERVICE LIMITED (GB) 2007-07-26 US disclosed
EP-1631995-A2 MANUFACTURE OF A POLYMER DEVICE CAMBRIDGE UNIVERSITY TECHNICAL SERVICES LIMITED (GB) 2006-03-08 EP disclosed
WO-2004100282-A2 MANUFACTURE OF A POLYMER DEVICE CAMBRIDGE UNIVERSITY TECHNICAL SERVICES LIMITED (GB) 2004-11-18 WO disclosed
US-6630513-B1 Capable of lowering plasma cholesterol levels and inhibiting abnormal cell proliferation, such as in cervical adenocarcinoma TULARIX INC. 2003-10-07 US disclosed
WO-2001012593-A1 ARYLSULFONANILIDE DERIVATIVES TULARIK INC. (US) 2001-02-22 WO disclosed
US-6153585-A FOR TREATING CANCER, PSORIASIS, VASCULAR RESTENOSIS, INFECTIONS, ATHEROSCLEROSIS AND HYPERCHOLESTEROLEMIA TULARIK INC. (US) 2000-11-28 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12559454-B2 Benzenesulfonamide derivatives and uses thereof NR2E1, NR2C2, NR3C1 CA1 2665/4885CA2 2232/4885CA12 2947/4885
US-20220281812-A1 BENZENESULFONAMIDE DERIVATIVES AND USES THEREOF BCR, ARSA, VHL CA1 4526/4885CA2 4102/4885CA12 4068/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.