Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.47 |
| ▸ | GSK3B | P49841 | 1/20 | 0.47 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | NOD1 | Q9Y239 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.44 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.42 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4581651 | 1.00 | NOS2 (0.49) | NOS2CYP1A2CYP2D6HTTRPS6KB1 | |
| SCHEMBL1980314 | 0.84 | HSD17B10 (0.57) | NOS2CYP1A2CYP2D6HTTRPS6KB1 | |
| SCHEMBL7847984 | 0.82 | NOS2 (0.55) | NOS2CYP1A2CYP2D6HTTRPS6KB1 | |
| Bromide SCHEMBL1982279 | 0.82 | HSD17B10 (0.56) | NOS2CYP1A2CYP2D6HTTRPS6KB1 | |
| SCHEMBL989291 | 0.78 | GRM5 (0.39) | CYP1A2CYP2D6HTTHSD17B10NOD1 | |
| SCHEMBL989292 | 0.78 | GRM5 (0.39) | CYP1A2CYP2D6HTTHSD17B10NOD1 | |
| SCHEMBL990060 | 0.78 | GRM5 (0.39) | CYP1A2CYP2D6HTTHSD17B10NOD1 | |
| SCHEMBL989513 | 0.77 | PI4KB (0.46) | KDM4ENPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL991367 | 0.77 | PI4KB (0.46) | KDM4ENPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL989515 | 0.77 | PI4KB (0.46) | KDM4ENPC1RAB9ASMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080227839-A1 | Kinase Inhibitors | ELI LILLY AND COMPANY | 2008-09-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080227839-A1 | Kinase Inhibitors | ABL1, MAP3K20, MAP3K19 | NOS2 3717/4885CYP1A2 3740/4885CYP2D6 2928/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.