Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 8/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.38 |
| ▸ | YAP1 | P46937 | 1/20 | 0.38 |
| ▸ | RORC | P51449 | 2/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL459391 | 0.93 | PDE4B (0.42) | PDE4BGRIN2BCYP2D6CYP2C9CYP3A4 | |
| SCHEMBL457195 | 0.91 | PDE4B (0.42) | PDE4BGRIN2BCYP2D6CYP2C9CYP3A4 | |
| SCHEMBL458155 | 0.87 | PDE4B (0.43) | PDE4BGRIN2BCYP2D6CYP2C9CYP3A4 | |
| SCHEMBL12064782 | 0.82 | PDE4B (0.42) | PDE4BGPR119YAP1RORC | |
| SCHEMBL12064593 | 0.81 | PDE4B (0.42) | PDE4BGRIN2BGPR119YAP1RORC | |
| SCHEMBL14730220 | 0.81 | TP53 (0.45) | PDE4BRORCCHRM4 | |
| SCHEMBL470782 | 0.80 | PDE4B (0.42) | PDE4BGRIN2BRORC | |
| SCHEMBL150998 | 0.78 | GPR119 (0.48) | GPR119CHRM4 | |
| SCHEMBL1720991 | 0.78 | GPR119 (0.48) | GPR119CHRM4 | |
| SCHEMBL14722527 | 0.78 | PDE4B (0.41) | PDE4BGPR119RORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011147951-A1 | CYCLOAMINO DERIVATIVES AS GPR119 ANTAGONISTS | PROSIDION LIMITED (GB) | 2011-12-01 | — | — | WO | disclosed |