Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH1 | O75874 | 17/20 | 0.44 |
| ▸ | IGF1R | P08069 | 3/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4581848 | 1.00 | IDH1 (0.44) | IDH1IGF1RNTRK1 | |
| SCHEMBL4580856 | 0.82 | IDH1 (0.56) | IDH1 | |
| SCHEMBL4581501 | 0.82 | IDH1 (0.56) | IDH1 | |
| SCHEMBL4581855 | 0.82 | IDH1 (0.56) | IDH1 | |
| SCHEMBL4581905 | 0.82 | IDH1 (0.56) | IDH1 | |
| SCHEMBL4581908 | 0.79 | ABL1 (0.42) | — | |
| SCHEMBL4581083 | 0.70 | IDH1 (0.44) | IDH1 | |
| SCHEMBL4583141 | 0.69 | IDH1 (0.55) | IDH1 | |
| SCHEMBL4581212 | 0.69 | IDH1 (0.43) | IDH1 | |
| SCHEMBL4581007 | 0.67 | HRH4 (0.54) | IDH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7323464-B2 | Pyridine and pyrimidine derivatives | CELLTECH R&D LIMITED (GB) | 2008-01-29 | — | — | US | disclosed |
| US-20050080258-A1 | Pyridine and pyrimidine derivatives | GENTEX CORPORATION | 2005-04-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050080258-A1 | Pyridine and pyrimidine derivatives | ROR1, MAPK1, IRAK1 | IDH1 424/4885IGF1R 207/4885NTRK1 901/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.