Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ANPEP | P15144 | 1/20 | 0.55 |
| ▸ | CTSL | P07711 | 1/20 | 0.45 |
| ▸ | CTSS | P25774 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | SIRT2 | Q8IXJ6 | 10/20 | 0.43 |
| ▸ | SIRT1 | Q96EB6 | 7/20 | 0.43 |
| ▸ | SIRT3 | Q9NTG7 | 4/20 | 0.43 |
| ▸ | TLR2 | O60603 | 1/20 | 0.42 |
| ▸ | SYK | P43405 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1596691 | 0.84 | CTSL (0.52) | CTSLCTSSSIRT2SIRT1SIRT3 | |
| SCHEMBL13434967 | 0.81 | SIRT2 (0.53) | CTSLCTSSSIRT2SIRT1SIRT3 | |
| SCHEMBL133032 | 0.81 | SIRT2 (0.53) | CTSLCTSSSIRT2SIRT1SIRT3 | |
| SCHEMBL3902571 | 0.81 | SIRT2 (0.53) | CTSLCTSSSIRT2SIRT1SIRT3 | |
| SCHEMBL130760 | 0.81 | MEN1 (0.51) | CTSLCTSSSIRT2SIRT1SIRT3 | |
| SCHEMBL8054994 | 0.80 | SIRT2 (0.55) | CTSLCTSSSIRT2SIRT1SIRT3 | |
| SCHEMBL1596702 | 0.78 | GAA (0.42) | ANPEPGAA | |
| SCHEMBL1596705 | 0.78 | GAA (0.42) | ANPEPGAA | |
| SCHEMBL3319289 | 0.77 | CTSL (0.56) | CTSLCTSSSIRT2SIRT1SYK | |
| SCHEMBL1734009 | 0.77 | CTSL (0.56) | CTSLCTSSSIRT2SIRT1SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1509218-A4 | PEPTIDE DEFORMYLASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2008-03-26 | — | — | EP | disclosed |
| EP-1509218-A1 | PEPTIDE DEFORMYLASE INHIBITORS | SmithKline Beecham Corporation (US) | 2005-03-02 | — | — | EP | disclosed |
| WO-2003101442-A1 | PEPTIDE DEFORMYLASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-12-11 | — | — | WO | disclosed |