SCHEMBL4582183

SCHEMBL4582183

CCCCC[C@@H](CN(O)C=O)C(=O)N(NC)c1nccc(C(F)(F)F)n1

nearest known ligand 0.42

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
BMP1 P13497 6/20 0.38
MMP12 P39900 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4582186 1.00 BMP1 (0.38) BMP1MMP12
SCHEMBL2783949 1.00 BMP1 (0.38) BMP1MMP12
SCHEMBL2782495 0.87 BMP1 (0.37) BMP1MMP12
SCHEMBL2782498 0.87 BMP1 (0.37) BMP1MMP12
SCHEMBL1594643 0.83 BMP1 (0.42) BMP1MMP12
SCHEMBL1594639 0.83 BMP1 (0.42) BMP1MMP12
SCHEMBL1594635 0.83 BMP1 (0.42) BMP1MMP12
SCHEMBL1595523 0.79 BMP1 (0.42) BMP1MMP12
SCHEMBL1595521 0.79 BMP1 (0.42) BMP1MMP12
SCHEMBL1595525 0.79 BMP1 (0.42) BMP1MMP12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1509218-A4 PEPTIDE DEFORMYLASE INHIBITORS SMITHKLINE BEECHAM CORP (US) 2008-03-26 EP disclosed
EP-1509218-A1 PEPTIDE DEFORMYLASE INHIBITORS SmithKline Beecham Corporation (US) 2005-03-02 EP disclosed
WO-2003101442-A1 PEPTIDE DEFORMYLASE INHIBITORS SMITHKLINE BEECHAM CORPORATION (US) 2003-12-11 WO disclosed