Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 3/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | ACE | P12821 | 5/20 | 0.52 |
| ▸ | GPR132 | Q9UNW8 | 1/20 | 0.52 |
| ▸ | NAALAD2 | Q9Y3Q0 | 1/20 | 0.51 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.51 |
| ▸ | TACR1 | P25103 | 1/20 | 0.51 |
| ▸ | PPARG | P37231 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 2/20 | 0.49 |
| ▸ | CPA1 | P15085 | 2/20 | 0.49 |
| ▸ | ACE2 | Q9BYF1 | 2/20 | 0.49 |
| ▸ | FPR2 | P25090 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28353707 | 0.89 | MME (0.61) | MMEL3MBTL1NPSR1ACEGPR132 | |
| SCHEMBL30090841 | 0.89 | MME (0.61) | MMEL3MBTL1NPSR1ACEGPR132 | |
| SCHEMBL9301046 | 0.87 | ALDH1A1 (0.61) | L3MBTL1TACR1PPARGCA2 | |
| SCHEMBL4182695 | 0.84 | MME (0.44) | MMEPPARGCA2CA1 | |
| SCHEMBL4173742 | 0.84 | MME (0.44) | MMEPPARGCA2CA1 | |
| SCHEMBL4178228 | 0.84 | MME (0.44) | MMEPPARGCA2CA1 | |
| SCHEMBL10566173 | 0.83 | TSHR (0.42) | PPARG | |
| SCHEMBL11059105 | 0.83 | GAA (0.48) | MMECA2CA1 | |
| SCHEMBL4819455 | 0.83 | GAA (0.48) | MMECA2CA1 | |
| SCHEMBL10566164 | 0.83 | TSHR (0.42) | PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1724260-B1 | Process for the synthesis of (2S, 3aR, 7aS)octahydroindole-2-carboxylic acid and its conversion to trandolapril | SOCHINAZ SA (CH) | 2008-02-20 | — | — | EP | disclosed |
| EP-1876168-A1 | Method for manufacturing beta amino alpha hydroxy carboxylic acid amides | Evonik Degussa GmbH (DE) | 2008-01-09 | — | — | EP | disclosed |
| EP-1724260-A1 | Process for the synthesis of ¬2S, 3aR, 7aS|-octahydroindole-2-carboxylic acid and its conversion to trandolapril | Sochinaz SA (CH) | 2006-11-22 | — | — | EP | disclosed |