SCHEMBL4582383

SCHEMBL4582383

Cc1c(C)c(C)c(CN=C=O)c(CN=C=O)c1C.O=C=NCc1ccccc1CN=C=O

nearest known ligand 0.37

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
GABRA1 P14867 1/20 0.37
GABRB2 P47870 1/20 0.37
CYP3A4 P08684 1/20 0.35
PDCD1 Q15116 1/20 0.32
CD274 Q9NZQ7 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29364508 0.85 GABRA1 (0.41) GABRA1GABRB2CYP3A4PDCD1CD274
SCHEMBL127043 0.85 GABRA1 (0.41) GABRA1GABRB2CYP3A4PDCD1CD274
Propane SCHEMBL28338597 0.84 GABRA1 (0.47) GABRA1GABRB2CYP3A4PDCD1CD274
SCHEMBL28225610 0.83 GABRA1 (0.40) GABRA1GABRB2CYP3A4
Benzene SCHEMBL28107745 0.83 GABRA1 (0.40) GABRA1GABRB2CYP3A4PDCD1CD274
Water SCHEMBL5172983 0.83 GABRA1 (0.40) GABRA1GABRB2CYP3A4
SCHEMBL20144 0.83 CYP3A4 (0.31) CYP3A4
SCHEMBL1457269 0.82 GABRA1 (0.50) GABRA1GABRB2CYP3A4
Trimethylammonium SCHEMBL28053835 0.82 GABRA1 (0.41) GABRA1GABRB2CYP3A4
Ammonia Solution, Strong SCHEMBL28288673 0.81 CYP3A4 (0.30) CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20080151373-A1 Optical Film, Polarizing Plate and Liquid Crystal Display JSR CORPORATION (JP) 2008-06-26 US disclosed