Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 10/20 | 0.59 |
| ▸ | HSP90AB1 | P08238 | 6/20 | 0.56 |
| ▸ | HSP90AA1 | P07900 | 5/20 | 0.56 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.56 |
| ▸ | TRAP1 | Q12931 | 1/20 | 0.56 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.47 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.47 |
| ▸ | F10 | P00742 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1221039 | 0.86 | HSP90AB1 (0.58) | OPRM1HSP90AB1HSP90AA1HSP90B1TRAP1 | |
| SCHEMBL4558724 | 0.84 | OPRM1 (0.73) | OPRM1HSP90AB1HSP90AA1HTTKMT2A | |
| SCHEMBL1220473 | 0.81 | HSP90AB1 (0.61) | OPRM1HSP90AB1HSP90AA1HSP90B1TRAP1 | |
| SCHEMBL8130698 | 0.81 | HSP90AB1 (0.71) | OPRM1HSP90AB1HSP90AA1HSP90B1TRAP1 | |
| SCHEMBL18574113 | 0.81 | HSP90AB1 (0.68) | OPRM1HSP90AB1HSP90AA1HSP90B1TRAP1 | |
| SCHEMBL27982267 | 0.80 | OPRM1 (0.60) | OPRM1HSP90AB1HSP90AA1HSP90B1TRAP1 | |
| SCHEMBL1220912 | 0.78 | HSP90AB1 (0.74) | OPRM1HSP90AB1HSP90AA1HSP90B1TRAP1 | |
| SCHEMBL1220914 | 0.78 | HSP90AB1 (0.74) | OPRM1HSP90AB1HSP90AA1HSP90B1TRAP1 | |
| SCHEMBL1220961 | 0.78 | HSP90AA1 (0.56) | OPRM1HSP90AB1HSP90AA1HSP90B1TRAP1 | |
| SCHEMBL8140956 | 0.78 | HSP90AB1 (0.65) | OPRM1HSP90AB1HSP90AA1HSP90B1TRAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7358370-B2 | Anticancer, inflammation, arthritis, angiogenesis, neurodegenerative diseases, fungal infections, malaria; Heat-shock protein 90 inhibitors; 4-(6,6-Dimethyl-4-oxo-3-methyl-4,5,6,7-tetrahydro-indazol-1-yl)-2-(3,4,5-trimethoxyanilino)-benzamide | SERENEX, INC. (US) | 2008-04-15 | — | — | US | disclosed |
| US-20060211737-A1 | Anticancer, inflammation, arthritis, angiogenesis, neurodegenerative diseases, fungal infections, malaria; Heat-shock protein 90 inhibitors; 4-(6,6-Dimethyl-4-oxo-3-methyl-4,5,6,7-tetrahydro-indazol-1-yl)-2-(3,4,5-trimethoxyanilino)-benzamide | ESANEX, INC. | 2006-09-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060211737-A1 | Anticancer, inflammation, arthritis, angiogenesis, neurodegenerative diseases, fungal infections, malaria; Heat-shock protein 90 inhibitors; 4-(6,6-Dimethyl-4-oxo-3-methyl-4,5,6,7-tetrahydro-indazol-1-yl)-2-(3,4,5-trimethoxyanilino)-benzamide | HSF1, HSPA4, HSP90AB1 | OPRM1 3870/4885HSP90AB1 3/4885HSP90AA1 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.