Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP3 | P42574 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | RPS6KA2 | Q15349 | 2/20 | 0.51 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | APAF1 | O14727 | 1/20 | 0.49 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.49 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.49 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4582642 | 1.00 | CASP3 (0.60) | CASP3KMT2ANPC1RAB9ARPS6KA2 | |
| SCHEMBL4784027 | 0.85 | TAAR1 (0.55) | CASP3KMT2ANPC1RAB9ANR1H3 | |
| SCHEMBL13919633 | 0.85 | CASP3 (0.44) | CASP3KMT2ANPC1RAB9ARPS6KA2 | |
| Hydrochloric Acid SCHEMBL4899590 | 0.84 | TAAR1 (0.54) | CASP3KMT2ANPC1NR1H3GAA | |
| SCHEMBL1529483 | 0.84 | EPHX1 (0.53) | CASP3GAA | |
| SCHEMBL2370243 | 0.84 | EPHX1 (0.53) | CASP3GAA | |
| SCHEMBL1529481 | 0.84 | EPHX1 (0.53) | CASP3GAA | |
| Hydrochloric Acid SCHEMBL1529614 | 0.82 | EPHX1 (0.52) | CASP3GAA | |
| Hydrochloric Acid SCHEMBL4778820 | 0.82 | EPHX1 (0.52) | CASP3GAA | |
| Hydrochloric Acid SCHEMBL4783273 | 0.82 | EPHX1 (0.52) | CASP3GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1968568-A2 | INHIBITORS OF Akt ACTIVITY | SmithKline Beecham Corporation (US) | 2008-09-17 | — | — | EP | disclosed |
| WO-2007076423-A2 | INHIBITORS OF Akt ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2007-07-05 | — | — | WO | disclosed |