SCHEMBL458277

SCHEMBL458277

NOC(=O)CCCCC(=O)O

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 4/20 0.58
TSHR P16473 6/20 0.55
NFKB1 P19838 2/20 0.55
PMP22 Q01453 1/20 0.55
CYP2D6 P10635 1/20 0.52
ALDH1A1 P00352 4/20 0.50
KMT2A Q03164 3/20 0.50
BLM P54132 2/20 0.50
NPSR1 Q6W5P4 2/20 0.50
THRB P10828 2/20 0.50
SLC22A6 Q4U2R8 2/20 0.50
MEN1 O00255 2/20 0.50
ALOX15 P16050 2/20 0.50
PLG P00747 1/20 0.50
SLC6A2 P23975 1/20 0.50
RECQL P46063 1/20 0.50
SLC6A3 Q01959 1/20 0.50
HDAC11 Q96DB2 4/20 0.48
GABRR3 A8MPY1 1/20 0.48
GABRP O00591 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Adipic Acid SCHEMBL810759 1.00 LMNA (0.58) LMNATSHRNFKB1PMP22CYP2D6
Ammonia Solution, Strong SCHEMBL28253015 0.97 LMNA (0.55) LMNATSHRNFKB1PMP22CYP2D6
SCHEMBL18383745 0.97 TSHR (0.60) LMNATSHRNFKB1PMP22CYP2D6
SCHEMBL27694697 0.97 TSHR (0.60) LMNATSHRNFKB1PMP22CYP2D6
SCHEMBL11486379 0.97 TSHR (0.60) LMNATSHRNFKB1PMP22CYP2D6
SCHEMBL17011633 0.97 TSHR (0.60) LMNATSHRNFKB1PMP22CYP2D6
SCHEMBL13115062 0.97 TSHR (0.60) LMNATSHRNFKB1PMP22CYP2D6
Adipic Acid SCHEMBL28333156 0.97 TSHR (0.56) LMNATSHRNFKB1PMP22CYP2D6
SCHEMBL11480082 0.97 TSHR (0.60) LMNATSHRNFKB1PMP22CYP2D6
Bicarbonate SCHEMBL14856388 0.97 LMNA (0.55) LMNATSHRNFKB1PMP22CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 59 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114540261-A Genetically engineered bacterium for producing aminoadipic acid 北京化工大学 2022-05-27 CN claimed
US-20150361217-A1 A Polyamide Resin and Its Application and Polyamide Composition Thereof ZHUHAI WANGO CHEMICAL CO., LTD. (CN) 2015-12-17 US claimed
EP-2944665-A1 POLYAMIDE RESIN AND USE THEREOF AND POLYAMIDE COMPOSITION CONSISTING OF SAME Kingfa Sci&Tech Co. Ltd. (CN) 2015-11-18 EP claimed
US-20120156737-A1 PREPARATION OF ALPHA-KETOPIMELIC ACID DSM IP ASSETS B.V. (NL) 2012-06-21 US claimed
US-20120028320-A1 PREPARATION OF ADIPIC ACID DSM IP ASSETS B.V. (NL) 2012-02-02 US claimed
EP-2406385-A2 PREPARATION OF ADIPIC ACID DSM IP Assets B.V. (NL) 2012-01-18 EP claimed
EP-2406384-A2 PREPARATION OF ALPHA-KETOPIMELIC ACID DSM IP Assets B.V. (NL) 2012-01-18 EP claimed
WO-2010104390-A2 PREPARATION OF ALPHA-KETOPIMELIC ACID DSM IP ASSETS B.V. (NL) 2010-09-16 WO claimed
WO-2010104391-A2 PREPARATION OF ADIPIC ACID DSM IP ASSETS B.V. (NL) 2010-09-16 WO claimed
CN-1303991-C Stabilized pharmaceutical preparations of gamma-aminobutyric acid derivative process for preparing the same WARNER LAMBERT CO (US) 2007-03-14 CN claimed
CN-1301155-A Stable pharmaceutical formulation of gamma-aminobutyric acid derivatives and process for preparing the same WARNER LAMBERT CO (US) 2001-06-27 CN claimed
EP-0342558-B1 2-amino-4,5-methyleneadipic acid compounds for treatment of CNS disorders SEARLE & CO (US) 1994-02-02 EP claimed
EP-0432994-A2 Excitatory amino acid antagonists as anti-emetic drugs Olney, John William (US) 1991-06-19 EP claimed
EP-4437319-A1 METHODS AND COMPOSITIONS FOR ANALYTE QUANTIFICATION Matterworks Inc (US) 2024-10-02 EP disclosed
CN-116457462-A Constructs for efficient and specific genome editing and uses thereof 工匠开发实验室公司 2023-07-18 CN disclosed
EP-3611254-B1 MICROORGANISMS AND METHODS FOR THE BIOSYNTHESIS OF HEXAMETHYLENEDIAMINE GENOMATICA INC (US) 2023-07-05 EP disclosed
US-5177109-A 2-amino-4,5-methyleneadipic acid compounds for treatment of CNS disorders G. D. SEARLE & CO. (US) 1993-01-05 US disclosed
EP-0432994-A2 Excitatory amino acid antagonists as anti-emetic drugs Olney, John William (US) 1991-06-19 EP disclosed
WO-1991001756-A1 METHOD FOR CHEMICAL PROMOTION OF THE EFFECTS OF LOW CURRENT TRANSCRANIAL ELECTROSTIMULATION SKOLNICK MALCOLM H (US) 1991-02-21 WO disclosed
EP-0342558-A2 2-amino-4,5-methyleneadipic acid compounds for treatment of CNS disorders G.D. Searle & Co. (US) 1989-11-23 EP disclosed