Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 10/20 | 0.84 |
| ▸ | PDPK1 | O15530 | 5/20 | 0.51 |
| ▸ | AKT2 | P31751 | 1/20 | 0.47 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.47 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4583609 | 0.91 | AKT1 (1.00) | AKT1AKT2AKT3MAP3K5 | |
| SCHEMBL4584695 | 0.90 | AKT1 (0.80) | AKT1PDPK1AKT2AKT3MAP3K5 | |
| SCHEMBL4583851 | 0.86 | AKT1 (0.76) | AKT1PDPK1AKT2AKT3MAP3K5 | |
| SCHEMBL8240049 | 0.86 | AKT1 (0.82) | AKT1AKT2AKT3 | |
| SCHEMBL4584324 | 0.84 | AKT1 (0.85) | AKT1AKT2AKT3MAP3K5 | |
| SCHEMBL29644967 | 0.78 | AKT1 (1.00) | AKT1AKT2AKT3 | |
| SCHEMBL21067542 | 0.78 | AKT1 (1.00) | AKT1AKT2AKT3 | |
| SCHEMBL4585624 | 0.78 | AKT1 (1.00) | AKT1AKT2AKT3 | |
| SCHEMBL8234014 | 0.77 | AKT1 (0.80) | AKT1AKT2AKT3 | |
| SCHEMBL4479178 | 0.77 | AKT1 (0.64) | AKT1PDPK1MAP3K5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1968568-A2 | INHIBITORS OF Akt ACTIVITY | SmithKline Beecham Corporation (US) | 2008-09-17 | — | — | EP | claimed |
| WO-2007076423-A2 | INHIBITORS OF Akt ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2007-07-05 | — | — | WO | claimed |
| EP-1968568-A2 | INHIBITORS OF Akt ACTIVITY | SmithKline Beecham Corporation (US) | 2008-09-17 | — | — | EP | disclosed |
| WO-2007076423-A2 | INHIBITORS OF Akt ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2007-07-05 | — | — | WO | disclosed |