Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 10/20 | 0.80 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.48 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.48 |
| ▸ | AKT2 | P31751 | 1/20 | 0.47 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.47 |
| ▸ | CDC7 | O00311 | 1/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.46 |
| ▸ | PIM1 | P11309 | 1/20 | 0.46 |
| ▸ | PRKACA | P17612 | 1/20 | 0.46 |
| ▸ | CDK2 | P24941 | 1/20 | 0.46 |
| ▸ | GSK3B | P49841 | 1/20 | 0.46 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.46 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.46 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.46 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.45 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4583056 | 0.90 | AKT1 (0.84) | AKT1AKT2AKT3PDPK1MAP3K5 | |
| SCHEMBL4583609 | 0.89 | AKT1 (1.00) | AKT1ROCK2ROCK1AKT2AKT3 | |
| SCHEMBL8234014 | 0.88 | AKT1 (0.80) | AKT1ROCK2ROCK1AKT2AKT3 | |
| SCHEMBL4582898 | 0.85 | AKT1 (0.64) | AKT1ROCK1AKT2AKT3PIM1 | |
| SCHEMBL4583851 | 0.84 | AKT1 (0.76) | AKT1AKT2AKT3PDPK1MAP3K5 | |
| SCHEMBL4584324 | 0.81 | AKT1 (0.85) | AKT1ROCK2ROCK1AKT2AKT3 | |
| SCHEMBL13887785 | 0.78 | AKT1 (0.53) | AKT1ROCK2ROCK1AKT3CDC7 | |
| SCHEMBL4602171 | 0.77 | AKT1 (0.76) | AKT1AKT2AKT3 | |
| SCHEMBL8240049 | 0.76 | AKT1 (0.82) | AKT1ROCK1AKT2AKT3PIM1 | |
| SCHEMBL29644967 | 0.76 | AKT1 (1.00) | AKT1AKT2AKT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1968568-A2 | INHIBITORS OF Akt ACTIVITY | SmithKline Beecham Corporation (US) | 2008-09-17 | — | — | EP | claimed |
| WO-2007076423-A2 | INHIBITORS OF Akt ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2007-07-05 | — | — | WO | claimed |
| EP-1968568-A2 | INHIBITORS OF Akt ACTIVITY | SmithKline Beecham Corporation (US) | 2008-09-17 | — | — | EP | disclosed |
| WO-2007076423-A2 | INHIBITORS OF Akt ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2007-07-05 | — | — | WO | disclosed |