Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IL6 | P05231 | 8/20 | 0.61 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 5/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.37 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4580209 | 0.92 | IL6 (0.68) | IL6CASP3MEN1KMT2APOLB | |
| SCHEMBL4579848 | 0.91 | IL6 (0.67) | IL6HTTCASP3MEN1KMT2A | |
| SCHEMBL4580906 | 0.91 | IL6 (0.66) | IL6CASP3MEN1KMT2ARAB9A | |
| SCHEMBL4152318 | 0.90 | IL6 (0.64) | IL6MEN1KMT2APOLBRXFP1 | |
| SCHEMBL4581945 | 0.89 | IL6 (0.68) | IL6CASP3MEN1KMT2AALDH1A1 | |
| SCHEMBL4581187 | 0.88 | IL6 (0.63) | IL6CASP3MEN1KMT2APOLB | |
| SCHEMBL13639355 | 0.88 | IL6 (0.63) | IL6CASP3MEN1KMT2ARAB9A | |
| SCHEMBL4579735 | 0.86 | IL6 (0.65) | IL6RAB9ASMN1; SMN2 | |
| SCHEMBL4130024 | 0.86 | IL6 (0.68) | IL6HTTCASP3MEN1KMT2A | |
| SCHEMBL4580423 | 0.86 | IL6 (0.72) | IL6MEN1KMT2AMAPK1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1995242-B1 | NOVEL 1,2,3,4-TETRAHYDROQUINOXALINE DERIVATIVE HAVING GLUCOCORTICOID RECEPTOR BINDING ACTIVITY | SANTEN PHARMACEUTICAL CO LTD (JP) | 2012-11-07 | — | — | EP | disclosed |
| EP-1995242-A1 | NOVEL 1,2,3,4-TETRAHYDROQUINOXALINE DERIVATIVE HAVING GLUCOCORTICOID RECEPTOR BINDING ACTIVITY | Santen Pharmaceutical Co., Ltd (JP) | 2008-11-26 | — | — | EP | disclosed |