Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | CNR2 | P34972 | 5/20 | 0.45 |
| ▸ | CNR1 | P21554 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CES2 | O00748 | 1/20 | 0.42 |
| ▸ | CES1 | P23141 | 1/20 | 0.42 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MMP2 | P08253 | 2/20 | 0.42 |
| ▸ | MMP3 | P08254 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12482254 | 0.80 | POLB (0.54) | MEN1KMT2ACNR2CNR1POLB | |
| SCHEMBL1991963 | 0.77 | POLB (0.50) | MEN1KMT2ACNR2CNR1POLB | |
| SCHEMBL834974 | 0.77 | POLB (0.50) | MEN1KMT2ACNR2CNR1POLB | |
| SCHEMBL4473658 | 0.77 | POLB (0.50) | MEN1KMT2ACNR2CNR1POLB | |
| SCHEMBL7894643 | 0.77 | MEN1 (0.56) | MEN1KMT2ACNR2CNR1POLB | |
| SCHEMBL16114842 | 0.77 | MEN1 (0.56) | MEN1KMT2ACNR2CNR1POLB | |
| SCHEMBL14943683 | 0.75 | MEN1 (0.55) | MEN1KMT2ACNR2CNR1POLB | |
| SCHEMBL16322617 | 0.75 | CES1 (0.48) | MEN1KMT2ACNR2CES2CES1 | |
| SCHEMBL12401203 | 0.74 | MEN1 (0.54) | MEN1KMT2ACNR2CNR1POLB | |
| SCHEMBL15219609 | 0.74 | MEN1 (0.54) | MEN1KMT2ACNR2CNR1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1968568-A2 | INHIBITORS OF Akt ACTIVITY | SmithKline Beecham Corporation (US) | 2008-09-17 | — | — | EP | disclosed |
| WO-2007076423-A2 | INHIBITORS OF Akt ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2007-07-05 | — | — | WO | disclosed |