Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 4/20 | 0.54 |
| ▸ | JAK3 | P52333 | 1/20 | 0.50 |
| ▸ | FLT3 | P36888 | 7/20 | 0.49 |
| ▸ | CDK2 | P24941 | 6/20 | 0.49 |
| ▸ | CDK1 | P06493 | 4/20 | 0.49 |
| ▸ | CCNB1 | P14635 | 4/20 | 0.49 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.49 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.49 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.49 |
| ▸ | CDK9 | P50750 | 2/20 | 0.49 |
| ▸ | CDK7 | P50613 | 2/20 | 0.49 |
| ▸ | CCNH | P51946 | 2/20 | 0.49 |
| ▸ | MNAT1 | P51948 | 2/20 | 0.49 |
| ▸ | SRC | P12931 | 2/20 | 0.49 |
| ▸ | ABL1 | P00519 | 2/20 | 0.49 |
| ▸ | BCR | P11274 | 2/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | CAMK2D | Q13557 | 3/20 | 0.47 |
| ▸ | SYK | P43405 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4379373 | 0.87 | JAK2 (0.73) | JAK2JAK3FLT3CDK2CDK1 | |
| SCHEMBL4558034 | 0.84 | JAK2 (0.58) | JAK2JAK3FLT3CDK2CDK1 | |
| SCHEMBL4380880 | 0.78 | JAK2 (0.72) | JAK2JAK3FLT3CDK2CDK1 | |
| SCHEMBL4379476 | 0.77 | JAK2 (0.76) | JAK2JAK3FLT3CDK2CDK1 | |
| SCHEMBL4603072 | 0.75 | JAK2 (0.54) | JAK2JAK3FLT3CDK2CDK1 | |
| SCHEMBL4378640 | 0.75 | JAK2 (0.51) | JAK2JAK3FLT3CDK2CDK1 | |
| SCHEMBL4382424 | 0.75 | JAK2 (0.76) | JAK2JAK3FLT3CDK2CDK1 | |
| SCHEMBL4378197 | 0.75 | JAK2 (0.72) | JAK2JAK3FLT3CDK2CDK1 | |
| SCHEMBL4377340 | 0.75 | JAK2 (0.72) | JAK2JAK3FLT3CDK2CDK1 | |
| SCHEMBL8236514 | 0.75 | JAK2 (0.82) | JAK2JAK3FLT3CDK2CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008124085-A2 | METHODS OF USING COMBINATIONS OF MEK AND JAK-2 INHIBITORS | EXELIXIS, INC. (US) | 2008-10-16 | — | — | WO | disclosed |