Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 4/20 | 0.58 |
| ▸ | JAK3 | P52333 | 1/20 | 0.55 |
| ▸ | CDK2 | P24941 | 6/20 | 0.53 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.53 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.53 |
| ▸ | CDK9 | P50750 | 2/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.52 |
| ▸ | FLT3 | P36888 | 7/20 | 0.51 |
| ▸ | CDK1 | P06493 | 4/20 | 0.51 |
| ▸ | CCNB1 | P14635 | 4/20 | 0.51 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.51 |
| ▸ | CDK7 | P50613 | 2/20 | 0.51 |
| ▸ | CCNH | P51946 | 2/20 | 0.51 |
| ▸ | MNAT1 | P51948 | 2/20 | 0.51 |
| ▸ | CAMK2D | Q13557 | 3/20 | 0.48 |
| ▸ | KIT | P10721 | 2/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | BCR | P11274 | 1/20 | 0.47 |
| ▸ | PLK4 | O00444 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4375224 | 0.88 | JAK2 (0.77) | JAK2JAK3CDK2CCNT1CCNA2 | |
| SCHEMBL4583374 | 0.84 | JAK2 (0.54) | JAK2JAK3CDK2CCNT1CCNA2 | |
| SCHEMBL4378640 | 0.80 | JAK2 (0.51) | JAK2JAK3CDK2CCNT1CCNA2 | |
| SCHEMBL8236514 | 0.78 | JAK2 (0.82) | JAK2JAK3CDK2CCNT1CCNA2 | |
| SCHEMBL4382278 | 0.78 | JAK2 (0.72) | JAK2JAK3CDK2CCNT1CCNA2 | |
| SCHEMBL4377047 | 0.78 | JAK2 (0.72) | JAK2JAK3CDK2CCNT1CCNA2 | |
| SCHEMBL4828753 | 0.77 | JAK2 (0.55) | JAK2JAK3CDK2CCNT1CCNA2 | |
| SCHEMBL4378380 | 0.77 | JAK2 (0.71) | JAK2JAK3CDK2CCNT1CCNA2 | |
| SCHEMBL4379799 | 0.76 | JAK2 (0.73) | JAK2JAK3CDK2CCNT1CCNA2 | |
| SCHEMBL4376481 | 0.76 | JAK2 (0.76) | JAK2JAK3CDK2CCNT1CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009017838-A2 | COMBINATIONS OF JAK-2 INHIBITORS AND OTHER AGENTS | EXELIXIS, INC. (US) | 2009-02-05 | — | — | WO | claimed |