Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP3 | P42574 | 3/20 | 0.46 |
| ▸ | GNRHR | P30968 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | RPS6KA2 | Q15349 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | LTA4H | P09960 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | UBE2N | P61088 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1530019 | 1.00 | CASP3 (0.46) | CASP3GNRHRALDH1A1RPS6KA2HTR1A | |
| SCHEMBL30890110 | 1.00 | CASP3 (0.46) | CASP3GNRHRALDH1A1RPS6KA2HTR1A | |
| SCHEMBL1530021 | 1.00 | CASP3 (0.46) | CASP3GNRHRALDH1A1RPS6KA2HTR1A | |
| Hydrochloric Acid SCHEMBL1529443 | 0.99 | CASP3 (0.44) | CASP3GNRHRALDH1A1RPS6KA2HTR1A | |
| SCHEMBL676621 | 0.89 | UBE2N (0.47) | CASP3GNRHRALDH1A1MAPK1UBE2N | |
| SCHEMBL676622 | 0.89 | UBE2N (0.47) | CASP3GNRHRALDH1A1MAPK1UBE2N | |
| SCHEMBL20912948 | 0.89 | UBE2N (0.47) | CASP3GNRHRALDH1A1MAPK1UBE2N | |
| SCHEMBL29559650 | 0.89 | UBE2N (0.47) | CASP3GNRHRALDH1A1MAPK1UBE2N | |
| Ammonia Solution, Strong SCHEMBL1530005 | 0.87 | UBE2N (0.46) | CASP3GNRHRALDH1A1MAPK1UBE2N | |
| SCHEMBL1529723 | 0.87 | CASP3 (0.57) | CASP3ALDH1A1RPS6KA2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112480116-B | PKB inhibitors | 南京正大天晴制药有限公司 | 2024-03-29 | — | — | CN | disclosed |
| CN-112480116-A | PKB inhibitors | 南京正大天晴制药有限公司 | 2021-03-12 | — | — | CN | disclosed |
| US-10654868-B2 | Dihydropyrazole azepine compound serving as Akt inhibitor | Harbin Zhenbao Pharmaceutical Co., Ltd. (CN) | 2020-05-19 | — | — | US | disclosed |
| US-20190233434-A1 | DIHYDROPYRAZOLE AZEPINE COMPOUND SERVING AS AKT INHIBITOR | Harbin Zhenbao Pharmaceutical Co., Ltd. (CN) | 2019-08-01 | — | — | US | disclosed |
| EP-3473628-A1 | DIHYDROPYRAZOLE AZEPINE COMPOUND SERVING AS AKT INHIBITOR | Medshine Discovery Inc. (CN) | 2019-04-24 | — | — | EP | disclosed |
| EP-1968568-A2 | INHIBITORS OF Akt ACTIVITY | SmithKline Beecham Corporation (US) | 2008-09-17 | — | — | EP | disclosed |
| WO-2007076423-A2 | INHIBITORS OF Akt ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2007-07-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10654868-B2 | Dihydropyrazole azepine compound serving as Akt inhibitor | AKT3, AKT2, AKT1 | CASP3 2070/4885GNRHR 3638/4885ALDH1A1 3338/4885 |
| US-20190233434-A1 | DIHYDROPYRAZOLE AZEPINE COMPOUND SERVING AS AKT INHIBITOR | AKT3, AKT2, AKT1 | CASP3 2070/4885GNRHR 3638/4885ALDH1A1 3338/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.