Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 16/20 | 0.59 |
| ▸ | JAK3 | P52333 | 10/20 | 0.57 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.54 |
| ▸ | JAK1 | P23458 | 3/20 | 0.53 |
| ▸ | TYK2 | P29597 | 2/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.53 |
| ▸ | NCOR1 | O75376 | 1/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.53 |
| ▸ | EGFR | P00533 | 3/20 | 0.53 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.52 |
| ▸ | PLK4 | O00444 | 1/20 | 0.52 |
| ▸ | CIT | O14578 | 1/20 | 0.52 |
| ▸ | GAK | O14976 | 1/20 | 0.52 |
| ▸ | OPA1 | O60313 | 1/20 | 0.52 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.52 |
| ▸ | STK16 | O75716 | 1/20 | 0.52 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4583408 | 0.89 | JAK2 (0.57) | JAK2JAK3ACVR1HDAC1HDAC6 | |
| SCHEMBL4602091 | 0.88 | GSK3B (0.57) | JAK2JAK3ACVR1HDAC1HDAC6 | |
| SCHEMBL4383888 | 0.85 | MEN1 (0.68) | JAK2JAK3HDAC1HDAC6JAK1 | |
| SCHEMBL4381182 | 0.85 | JAK2 (0.60) | JAK2JAK3ACVR1HDAC1HDAC6 | |
| SCHEMBL4377671 | 0.85 | JAK2 (0.80) | JAK2JAK3HDAC1HDAC6JAK1 | |
| SCHEMBL4384824 | 0.85 | JAK2 (0.57) | JAK2JAK3ACVR1HDAC1HDAC6 | |
| SCHEMBL4830383 | 0.85 | JAK2 (0.53) | JAK2JAK3HDAC1HDAC6JAK1 | |
| SCHEMBL4382690 | 0.85 | JAK2 (0.58) | JAK2JAK3EGFR | |
| SCHEMBL4384815 | 0.83 | JAK2 (0.78) | JAK2JAK3HDAC1HDAC6JAK1 | |
| SCHEMBL4376799 | 0.83 | JAK2 (0.68) | JAK2JAK3HDAC1HDAC6JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008124085-A2 | METHODS OF USING COMBINATIONS OF MEK AND JAK-2 INHIBITORS | EXELIXIS, INC. (US) | 2008-10-16 | — | — | WO | disclosed |