Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 18/20 | 0.57 |
| ▸ | JAK3 | P52333 | 10/20 | 0.52 |
| ▸ | JAK1 | P23458 | 5/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.52 |
| ▸ | TYK2 | P29597 | 3/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.52 |
| ▸ | NCOR1 | O75376 | 1/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.52 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.51 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.50 |
| ▸ | FLT3 | P36888 | 2/20 | 0.50 |
| ▸ | IKBKB | O14920 | 1/20 | 0.50 |
| ▸ | KIT | P10721 | 1/20 | 0.50 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.50 |
| ▸ | FLT1 | P17948 | 1/20 | 0.50 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.50 |
| ▸ | FLT4 | P35916 | 1/20 | 0.50 |
| ▸ | KDR | P35968 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4584094 | 0.89 | JAK2 (0.59) | JAK2JAK3JAK1HDAC1TYK2 | |
| SCHEMBL4602091 | 0.86 | GSK3B (0.57) | JAK2JAK3JAK1HDAC1TYK2 | |
| SCHEMBL4393252 | 0.85 | JAK2 (0.75) | JAK2JAK3JAK1HDAC1TYK2 | |
| SCHEMBL4830383 | 0.84 | JAK2 (0.53) | JAK2JAK3JAK1HDAC1TYK2 | |
| SCHEMBL4381182 | 0.82 | JAK2 (0.60) | JAK2JAK3JAK1HDAC1TYK2 | |
| SCHEMBL4382350 | 0.81 | JAK2 (0.76) | JAK2JAK3JAK1HDAC1TYK2 | |
| SCHEMBL4584356 | 0.79 | JAK2 (0.52) | JAK2JAK3HDAC1HDAC6 | |
| SCHEMBL4828914 | 0.79 | JAK2 (0.52) | JAK2JAK3JAK1HDAC1TYK2 | |
| SCHEMBL3759170 | 0.77 | MAPK8 (0.71) | JAK2JAK3HDAC1HDAC6IKBKB | |
| SCHEMBL4385527 | 0.76 | JAK2 (0.76) | JAK2JAK3HDAC1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008124085-A2 | METHODS OF USING COMBINATIONS OF MEK AND JAK-2 INHIBITORS | EXELIXIS, INC. (US) | 2008-10-16 | — | — | WO | claimed |