Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 18/20 | 0.86 |
| ▸ | AKT2 | P31751 | 1/20 | 0.47 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.47 |
| ▸ | CIT | O14578 | 1/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4582878 | 0.92 | AKT1 (1.00) | AKT1AKT2AKT3CIT | |
| SCHEMBL8244311 | 0.87 | AKT1 (0.65) | AKT1AKT3ROCK2 | |
| SCHEMBL8234017 | 0.83 | AKT1 (0.61) | AKT1AKT2AKT3CITROCK2 | |
| SCHEMBL8233640 | 0.81 | AKT1 (0.73) | AKT1AKT2AKT3CIT | |
| SCHEMBL4592533 | 0.81 | AKT1 (0.73) | AKT1AKT2AKT3 | |
| SCHEMBL4583126 | 0.81 | AKT1 (0.68) | AKT1AKT2AKT3CIT | |
| SCHEMBL8240562 | 0.81 | AKT1 (0.70) | AKT1AKT2AKT3CIT | |
| SCHEMBL4585345 | 0.81 | AKT1 (0.70) | AKT1AKT2AKT3CIT | |
| SCHEMBL8242629 | 0.81 | AKT1 (0.70) | AKT1AKT2AKT3CIT | |
| SCHEMBL8233616 | 0.79 | AKT1 (0.76) | AKT1AKT3ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1968568-A2 | INHIBITORS OF Akt ACTIVITY | SmithKline Beecham Corporation (US) | 2008-09-17 | — | — | EP | claimed |
| WO-2007076423-A2 | INHIBITORS OF Akt ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2007-07-05 | — | — | WO | claimed |
| EP-1968568-A2 | INHIBITORS OF Akt ACTIVITY | SmithKline Beecham Corporation (US) | 2008-09-17 | — | — | EP | disclosed |
| WO-2007076423-A2 | INHIBITORS OF Akt ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2007-07-05 | — | — | WO | disclosed |
| WO-2007076423-A2 | INHIBITORS OF Akt ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2007-07-05 | — | — | WO | disclosed |