Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 17/20 | 0.70 |
| ▸ | AKT2 | P31751 | 1/20 | 0.46 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.46 |
| ▸ | CIT | O14578 | 2/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4583126 | 0.90 | AKT1 (0.68) | AKT1AKT2AKT3CITROCK1 | |
| SCHEMBL4592533 | 0.89 | AKT1 (0.73) | AKT1AKT2AKT3 | |
| SCHEMBL4582878 | 0.82 | AKT1 (1.00) | AKT1AKT2AKT3CIT | |
| SCHEMBL4584377 | 0.81 | AKT1 (0.86) | AKT1AKT2AKT3CIT | |
| SCHEMBL8242629 | 0.80 | AKT1 (0.70) | AKT1AKT2AKT3CIT | |
| SCHEMBL14494746 | 0.79 | AKT1 (0.60) | AKT1CITROCK1 | |
| SCHEMBL4582661 | 0.78 | AKT1 (0.71) | AKT1AKT2AKT3 | |
| SCHEMBL8233640 | 0.77 | AKT1 (0.73) | AKT1AKT2AKT3CITROCK1 | |
| SCHEMBL4582644 | 0.75 | AKT1 (1.00) | AKT1AKT2AKT3ROCK1 | |
| SCHEMBL8240562 | 0.73 | AKT1 (0.70) | AKT1AKT2AKT3CIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1968568-A2 | INHIBITORS OF Akt ACTIVITY | SmithKline Beecham Corporation (US) | 2008-09-17 | — | — | EP | claimed |
| WO-2007076423-A2 | INHIBITORS OF Akt ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2007-07-05 | — | — | WO | claimed |
| WO-2007076423-A2 | INHIBITORS OF Akt ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2007-07-05 | — | — | WO | disclosed |