SCHEMBL4584431

SCHEMBL4584431

CSc1nccc(-c2[nH]c(CCCN3CCOCC3)nc2-c2ccc(F)cc2)n1

nearest known ligand 0.64

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
MAPK14 Q16539 19/20 0.64
MAPK13 O15264 15/20 0.64
MAPK12 P53778 15/20 0.64
MAPK11 Q15759 15/20 0.64
CSNK1D P48730 2/20 0.52
JAK3 P52333 1/20 0.52
EGFR P00533 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4584803 0.86 MAPK14 (0.62) MAPK14MAPK13MAPK12MAPK11
SCHEMBL4584585 0.83 MAPK14 (0.52) MAPK14MAPK13MAPK12MAPK11
SCHEMBL4584122 0.81 MAPK14 (0.50) MAPK14MAPK13MAPK12MAPK11EGFR
SCHEMBL4585385 0.80 ALOX5 (0.62) MAPK14MAPK13MAPK12MAPK11CSNK1D
SCHEMBL4584037 0.79 MAPK14 (0.61) MAPK14MAPK13MAPK12MAPK11EGFR
SCHEMBL4586000 0.79 MAPK14 (0.61) MAPK14MAPK13MAPK12MAPK11EGFR
SCHEMBL4918512 0.78 MAPK13 (1.00) MAPK14MAPK13MAPK12MAPK11
SCHEMBL4585395 0.77 ALOX5 (0.61) MAPK14MAPK13MAPK12MAPK11CSNK1D
SCHEMBL4584913 0.77 MAPK14 (0.64) MAPK14MAPK13MAPK12MAPK11EGFR
SCHEMBL8318559 0.76 MAPK13 (0.86) MAPK14MAPK13MAPK12MAPK11

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1539121-A4 METHODS OF PROMOTING OSTEOGENESIS SCIOS INC (US) 2008-08-13 EP disclosed
EP-1545535-A4 TREATMENT OF PAIN BY INHIBITION OF P38 MAP KINASE SCIOS INC (US) 2008-06-04 EP disclosed
EP-1583535-A4 METHODS FOR TREATING DIABETES SCIOS INC (US) 2008-03-19 EP disclosed
EP-1583535-A2 METHODS FOR TREATING DIABETES SCIOS INC. (US) 2005-10-12 EP disclosed
EP-1545535-A2 TREATMENT OF PAIN BY INHIBITION OF P38 MAP KINASE SCIOS INC. (US) 2005-06-29 EP disclosed
EP-1539121-A2 METHODS OF PROMOTING OSTEOGENESIS SCIOS INC. (US) 2005-06-15 EP disclosed
WO-2004053107-A2 METHODS FOR TREATING DIABETES SCIOS INC. (US) 2004-06-24 WO disclosed
WO-2004021988-A2 TREATMENT OF PAIN BY INHIBITION OF P38 MAP KINASE SCIOS INC. (US) 2004-03-18 WO disclosed
WO-2004019873-A2 METHODS OF PROMOTING OSTEOGENESIS SCIOS INC. (US) 2004-03-11 WO disclosed
US-5864036-A Substituted imidazole compounds SMITHKLINE BEECHAM CORPORATION (US) 1999-01-26 US disclosed
US-5756499-A Substituted imidazole compounds SMITHKLINE BEECHAM CORPORATION (US) 1998-05-26 US disclosed