Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 20/20 | 0.54 |
| ▸ | GPR183 | P32249 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL462904 | 0.88 | GPR119 (0.54) | GPR119GPR183CYP3A4CYP2C19 | |
| SCHEMBL461135 | 0.84 | GPR119 (0.61) | GPR119GPR183 | |
| SCHEMBL470452 | 0.83 | GPR119 (0.51) | GPR119GPR183CYP3A4CYP2C19 | |
| SCHEMBL120996 | 0.81 | GPR119 (0.52) | GPR119GPR183 | |
| SCHEMBL149310 | 0.81 | GPR119 (0.48) | GPR119GPR183 | |
| SCHEMBL121152 | 0.81 | GPR119 (0.48) | GPR119GPR183 | |
| SCHEMBL14157542 | 0.79 | GPR119 (0.46) | GPR119CYP3A4CYP2C19 | |
| SCHEMBL14157541 | 0.79 | GPR119 (0.46) | GPR119CYP3A4CYP2C19 | |
| SCHEMBL470583 | 0.78 | GPR119 (0.47) | GPR119GPR183 | |
| SCHEMBL1895858 | 0.78 | GPR119 (0.50) | GPR119CYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011147951-A1 | CYCLOAMINO DERIVATIVES AS GPR119 ANTAGONISTS | PROSIDION LIMITED (GB) | 2011-12-01 | — | — | WO | disclosed |