Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 11/20 | 0.69 |
| ▸ | MAPK13 | O15264 | 8/20 | 0.69 |
| ▸ | MAPK12 | P53778 | 8/20 | 0.69 |
| ▸ | MAPK11 | Q15759 | 8/20 | 0.69 |
| ▸ | GCGR | P47871 | 5/20 | 0.69 |
| ▸ | ALOX5 | P09917 | 7/20 | 0.68 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.46 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.46 |
| ▸ | FRK | P42685 | 1/20 | 0.46 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.46 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.46 |
| ▸ | GSK3B | P49841 | 1/20 | 0.46 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.46 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.46 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.46 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.46 |
| ▸ | BRAF | P15056 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1387923 | 0.82 | MAPK14 (0.49) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL4565990 | 0.81 | ALOX5 (1.00) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL4583063 | 0.81 | MAPK14 (0.61) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL1387897 | 0.80 | MAPK14 (0.48) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL1387979 | 0.79 | MAPK14 (0.72) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL27311898 | 0.79 | MAPK13 (0.67) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL1387650 | 0.78 | MAPK14 (0.69) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL19869018 | 0.77 | MAPK14 (0.65) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL1387884 | 0.77 | MAPK14 (0.68) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL1387728 | 0.77 | MAPK14 (0.67) | MAPK14MAPK13MAPK12MAPK11GCGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1539121-A4 | METHODS OF PROMOTING OSTEOGENESIS | SCIOS INC (US) | 2008-08-13 | — | — | EP | disclosed |
| EP-1545535-A4 | TREATMENT OF PAIN BY INHIBITION OF P38 MAP KINASE | SCIOS INC (US) | 2008-06-04 | — | — | EP | disclosed |
| EP-1583535-A4 | METHODS FOR TREATING DIABETES | SCIOS INC (US) | 2008-03-19 | — | — | EP | disclosed |
| EP-1583535-A2 | METHODS FOR TREATING DIABETES | SCIOS INC. (US) | 2005-10-12 | — | — | EP | disclosed |
| EP-1545535-A2 | TREATMENT OF PAIN BY INHIBITION OF P38 MAP KINASE | SCIOS INC. (US) | 2005-06-29 | — | — | EP | disclosed |
| EP-1539121-A2 | METHODS OF PROMOTING OSTEOGENESIS | SCIOS INC. (US) | 2005-06-15 | — | — | EP | disclosed |
| WO-2005032551-A1 | TREATMENT OF CARDIOVASCULAR DISEASE WITH INHIBITORS OF p38 KINASE | SCIOS INC. (US) | 2005-04-14 | — | — | WO | disclosed |
| WO-2005030091-A2 | STENTS AND INTRA-LUMINAL PROSTHESES CONTAINING MAP KINASE INHIBITORS | SCIOS INC. (US) | 2005-04-07 | — | — | WO | disclosed |
| WO-2004019873-A9 | METHODS OF PROMOTING OSTEOGENESIS | SCIOS INC (US) | 2004-06-24 | — | — | WO | disclosed |
| WO-2004053107-A2 | METHODS FOR TREATING DIABETES | SCIOS INC. (US) | 2004-06-24 | — | — | WO | disclosed |
| WO-2004024083-A2 | METHODS OF BONE HEALING | UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY (US) | 2004-03-25 | — | — | WO | disclosed |
| WO-2004021988-A2 | TREATMENT OF PAIN BY INHIBITION OF P38 MAP KINASE | SCIOS INC. (US) | 2004-03-18 | — | — | WO | disclosed |
| WO-2004019873-A2 | METHODS OF PROMOTING OSTEOGENESIS | SCIOS INC. (US) | 2004-03-11 | — | — | WO | disclosed |
| EP-1021173-A1 | USE OF CSAID?TM COMPOUNDS FOR THE MANAGEMENT OF UTERINE CONTRACTIONS | IMPERIAL COLLEGE INNOVATIONS LIMITED (GB) | 2000-07-26 | — | — | EP | disclosed |
| WO-1999018942-A1 | USE OF CSAIDTM COMPOUNDS FOR THE MANAGEMENT OF UTERINE CONTRACTIONS | IMPERIAL COLLEGE INNOVATIONS LTD. (GB) | 1999-04-22 | — | — | WO | disclosed |