Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 10/20 | 0.48 |
| ▸ | ADORA1 | P30542 | 8/20 | 0.48 |
| ▸ | ADORA2B | P29275 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | USP2 | O75604 | 4/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.40 |
| ▸ | CASP1 | P29466 | 4/20 | 0.40 |
| ▸ | CASP7 | P55210 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | FYN | P06241 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4585503 | 0.87 | ADORA2A (0.65) | ADORA2AADORA1MEN1USP2CYP1A2 | |
| SCHEMBL4584719 | 0.82 | ADORA2A (0.58) | ADORA2AADORA1ADORA2BBRD4DYRK1A | |
| SCHEMBL1553233 | 0.81 | ADORA2A (0.62) | ADORA2AADORA1ADORA2BMEN1USP2 | |
| SCHEMBL4585799 | 0.79 | ADORA2A (0.75) | ADORA2AADORA1ADORA2BCYP1A2CYP3A4 | |
| SCHEMBL4584034 | 0.78 | ADORA2A (0.49) | ADORA2AADORA1ADORA2BMEN1KMT2A | |
| SCHEMBL4584950 | 0.78 | ADORA2A (0.49) | ADORA2AADORA1ADORA2B | |
| SCHEMBL4584321 | 0.78 | ADORA2A (0.68) | ADORA2AADORA1ADORA2BMEN1USP2 | |
| SCHEMBL28463384 | 0.76 | ADORA2A (0.55) | ADORA2AADORA1ADORA2BBRD4DYRK1A | |
| SCHEMBL3053862 | 0.74 | CYP3A4 (0.45) | ADORA2AADORA1ADORA2BMEN1CYP1A2 | |
| SCHEMBL27646771 | 0.73 | ADORA2A (0.45) | ADORA2AADORA1ADORA2BBRD4DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7407961-B2 | Pyrazine derivatives and pharmaceutical use thereof | ASTELLAS PHARMA INC. (JP) | 2008-08-05 | — | — | US | disclosed |
| CN-1871231-A | Pyrazine derivatives and pharmaceutical use thereof | ASTELLAS PHARMA INC (JP) | 2006-11-29 | — | — | CN | disclosed |
| US-20050113387-A1 | Pyrazine derivatives and pharmaceutical use thereof | FUJISAWA PHARMACEUTICAL CO. LTD. (JP) | 2005-05-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050113387-A1 | Pyrazine derivatives and pharmaceutical use thereof | ADORA2A, P2RX5, ADORA1 | ADORA2A 1/4885ADORA1 3/4885ADORA2B 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.