Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 10/20 | 0.51 |
| ▸ | HPGDS | O60760 | 4/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.40 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.40 |
| ▸ | AKT2 | P31751 | 3/20 | 0.39 |
| ▸ | AKT3 | Q9Y243 | 3/20 | 0.39 |
| ▸ | CDC7 | O00311 | 1/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
| ▸ | IKBKB | O14920 | 1/20 | 0.38 |
| ▸ | CHUK | O15111 | 1/20 | 0.38 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.38 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.38 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.38 |
| ▸ | PRKCG | P05129 | 1/20 | 0.38 |
| ▸ | INSR | P06213 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8243230 | 0.88 | AKT1 (0.52) | AKT1HPGDSDYRK1ADYRK1BAKT2 | |
| SCHEMBL8240130 | 0.80 | AKT1 (0.43) | AKT1DYRK1ADYRK1BAKT2AKT3 | |
| SCHEMBL4583196 | 0.78 | AKT1 (0.53) | AKT1DYRK1ADYRK1BAKT2AKT3 | |
| SCHEMBL4583583 | 0.77 | AKT1 (0.52) | AKT1DYRK1ADYRK1BAKT2AKT3 | |
| SCHEMBL4592997 | 0.74 | AKT1 (0.43) | AKT1HPGDSDYRK1ADYRK1BAKT2 | |
| SCHEMBL4583406 | 0.72 | AKT1 (0.67) | AKT1DYRK1ADYRK1BAKT2AKT3 | |
| SCHEMBL8239982 | 0.71 | AKT1 (0.46) | AKT1DYRK1ADYRK1BAKT2AKT3 | |
| SCHEMBL4584417 | 0.70 | AKT1 (0.73) | AKT1AKT2AKT3MAPKAPK2GSK3B | |
| SCHEMBL8233639 | 0.70 | AKT1 (0.73) | AKT1AKT2AKT3MAPKAPK2GSK3B | |
| SCHEMBL4582555 | 0.69 | AKT1 (0.71) | AKT1AKT2AKT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1968568-A2 | INHIBITORS OF Akt ACTIVITY | SmithKline Beecham Corporation (US) | 2008-09-17 | — | — | EP | disclosed |
| WO-2007076423-A2 | INHIBITORS OF Akt ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2007-07-05 | — | — | WO | disclosed |