Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 10/20 | 0.43 |
| ▸ | AKT3 | Q9Y243 | 4/20 | 0.36 |
| ▸ | AKT2 | P31751 | 3/20 | 0.36 |
| ▸ | HPGDS | O60760 | 5/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4583196 | 0.83 | AKT1 (0.53) | AKT1AKT3AKT2DYRK1ADYRK1B | |
| SCHEMBL4537535 | 0.76 | HPGDS (0.41) | AKT3HPGDSDYRK1ADYRK1B | |
| SCHEMBL4543913 | 0.74 | HPGDS (0.36) | AKT1AKT3HPGDSDYRK1ADYRK1B | |
| SCHEMBL4382189 | 0.74 | ACKR3 (0.43) | — | |
| SCHEMBL4375386 | 0.74 | ACKR3 (0.43) | — | |
| SCHEMBL4584698 | 0.74 | AKT1 (0.51) | AKT1AKT3AKT2HPGDSDYRK1A | |
| SCHEMBL4544034 | 0.73 | HPGDS (0.38) | HPGDSDYRK1ADYRK1B | |
| SCHEMBL8243230 | 0.73 | AKT1 (0.52) | AKT1AKT3AKT2HPGDSDYRK1A | |
| SCHEMBL4583583 | 0.73 | AKT1 (0.52) | AKT1AKT3AKT2DYRK1ADYRK1B | |
| SCHEMBL8240130 | 0.71 | AKT1 (0.43) | AKT1AKT3AKT2DYRK1ADYRK1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1968568-A2 | INHIBITORS OF Akt ACTIVITY | SmithKline Beecham Corporation (US) | 2008-09-17 | — | — | EP | disclosed |
| WO-2007076423-A2 | INHIBITORS OF Akt ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2007-07-05 | — | — | WO | disclosed |