Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 5/20 | 0.46 |
| ▸ | HPGD | P15428 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.46 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.46 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.46 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.46 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | PLK4 | O00444 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL420359 | 0.84 | RAB9A (0.43) | NOTUMMAPTNPC1SMN1; SMN2MEN1 | |
| SCHEMBL1825175 | 0.79 | MAPK14 (0.60) | NOTUMHPGDKDM4EALDH1A1LMNA | |
| SCHEMBL1821560 | 0.78 | KDM4E (0.71) | NOTUMHPGDKDM4EALDH1A1LMNA | |
| SCHEMBL12496517 | 0.76 | MAPK14 (0.61) | NOTUMHPGDKDM4EALDH1A1LMNA | |
| SCHEMBL25356536 | 0.74 | HSD17B10 (0.50) | NOTUMHPGDKDM4EALDH1A1LMNA | |
| SCHEMBL16904654 | 0.74 | MEN1 (0.61) | NOTUMHPGDKDM4EALDH1A1LMNA | |
| SCHEMBL915201 | 0.72 | SNCA (0.52) | HPGDKDM4EALDH1A1LMNAMAPT | |
| SCHEMBL899479 | 0.71 | GSK3B (0.61) | KDM4EALDH1A1LMNABCL2L1MAPT | |
| Hydrochloric Acid SCHEMBL8935203 | 0.70 | GSK3B (0.59) | KDM4EALDH1A1LMNABCL2L1MAPT | |
| Bromide SCHEMBL8935164 | 0.70 | GSK3B (0.59) | KDM4EALDH1A1LMNABCL2L1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1968568-A2 | INHIBITORS OF Akt ACTIVITY | SmithKline Beecham Corporation (US) | 2008-09-17 | — | — | EP | disclosed |
| WO-2007076423-A2 | INHIBITORS OF Akt ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2007-07-05 | — | — | WO | disclosed |
| WO-2007076423-A2 | INHIBITORS OF Akt ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2007-07-05 | — | — | WO | disclosed |