Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | RARB | P10826 | 1/20 | 0.39 |
| ▸ | RARG | P13631 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.39 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tert-Butylbenzene SCHEMBL29171481 | 1.00 | MAPK1 (0.42) | MAPK1MAPTKMT2AL3MBTL1TDP1 | |
| Tert-Butylbenzene SCHEMBL27805700 | 0.90 | MAPK1 (0.46) | MAPK1MAPTKMT2AL3MBTL1TDP1 | |
| SCHEMBL6751140 | 0.85 | ESR1 (0.54) | MAPK1MAPTKMT2ATSHRCYP2C19 | |
| SCHEMBL28301318 | 0.85 | ESR1 (0.54) | MAPK1MAPTKMT2ATSHRCYP2C19 | |
| SCHEMBL27921692 | 0.85 | ESR1 (0.54) | MAPK1MAPTKMT2ATSHRCYP2C19 | |
| SCHEMBL658821 | 0.85 | ESR1 (0.54) | MAPK1MAPTKMT2ATSHRCYP2C19 | |
| SCHEMBL5694067 | 0.85 | ESR1 (0.54) | MAPK1MAPTKMT2ATSHRCYP2C19 | |
| SCHEMBL2517256 | 0.85 | ESR1 (0.54) | MAPK1MAPTKMT2ATSHRCYP2C19 | |
| Tert-Butylbenzene SCHEMBL2886541 | 0.85 | MAPK1 (0.42) | MAPK1MAPTKMT2AL3MBTL1TDP1 | |
| SCHEMBL1369038 | 0.85 | ESR1 (0.54) | MAPK1MAPTKMT2ATSHRCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106632940-A | Polycarbodiimide compounds, preparation method thereof and liquid type hydrolysis-resistant agent composition | 上海华峰新材料研发科技有限公司 | 2017-05-10 | — | — | CN | claimed |
| CN-117736163-A | Phenylpiperazine derivative or pharmaceutical salt thereof, preparation method and application thereof in preparation of pain treatment drugs | 郑州大学第一附属医院 | 2024-03-22 | — | — | CN | disclosed |
| CN-109526952-B | Glycosylated pesticide nano microcapsule and preparation method thereof | 山东农业大学 | 2021-12-17 | — | — | CN | disclosed |
| CN-106632940-A | Polycarbodiimide compounds, preparation method thereof and liquid type hydrolysis-resistant agent composition | 上海华峰新材料研发科技有限公司 | 2017-05-10 | — | — | CN | disclosed |
| US-20160068559-A1 | Modulators of Histone Methyltransferase, and Methods of Use Thereof | Epizyme, Inc. | 2016-03-10 | — | — | US | disclosed |
| US-9029343-B2 | Modulators of histone methyltransferase, and methods of use thereof | Epizyme, Inc. (US) | 2015-05-12 | — | — | US | disclosed |
| US-20130310333-A1 | Modulators of Histone Methyltransferase, and Methods of Use Thereof | Epizyme, Inc. (US) | 2013-11-21 | — | — | US | disclosed |
| EP-2646455-A2 | MODULATORS OF HISTONE METHYLTRANSFERASE, AND METHODS OF USE THEREOF | Epizyme, Inc. (US) | 2013-10-09 | — | — | EP | disclosed |
| WO-2012082436-A2 | MODULATORS OF HISTONE METHYLTRANSFERASE, AND METHODS OF USE THEREOF | Epizyme, Inc. (US) | 2012-06-21 | — | — | WO | disclosed |
| US-20080206103-A1 | Method For The Preparation Of Very Stable, Self-Assembled Monolayers On The Surface Of Gold Coated Microcantilevers For Application To Chemical Sensing | UT-BATTELLE, LLC (US) | 2008-08-28 | — | — | US | disclosed |
| EP-1794580-A2 | SELF-ASSEMBLED MONOLAYERS ON THE SURFACE OF GOLD COATED MICROCANTILEVERS FOR APPLICATION TO CHEMICAL SENSING AND METHOD OF PREPARATION | UT-Battelle, LLC (US) | 2007-06-13 | — | — | EP | disclosed |
| WO-2006031846-A2 | SELF-ASSEMBLED MONOLAYERS ON THE SURFACE OF GOLD COATED MICROCANTILEVERS FOR APPLICATION TO CHEMICAL SENSING AND METHOD OF OPERATION | UT-BATTELLE, LLC (US) | 2006-03-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160068559-A1 | Modulators of Histone Methyltransferase, and Methods of Use Thereof | EHMT1, EHMT2, HNMT | MAPK1 3455/4885MAPT 1361/4885KMT2A 23/4885 |
| US-20130310333-A1 | Modulators of Histone Methyltransferase, and Methods of Use Thereof | EHMT1, EHMT2, HNMT | MAPK1 3455/4885MAPT 1361/4885KMT2A 23/4885 |
| US-20080206103-A1 | Method For The Preparation Of Very Stable, Self-Assembled Monolayers On The Surface Of Gold Coated Microcantilevers For Application To Chemical Sensing | CALU, CALR, CALD1 | MAPK1 3392/4885MAPT 3957/4885KMT2A 2879/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.